Chemotherapy is one of the most commonly utilized approaches to treat malignant tumor. However, the well-controlled chemotherapy able to accurately manipulate local drugs for on-demand tumor treatment is still a challenge. Herein, a magnet and light dual-responsive hydrogel combining thermosensitive poly(N-acryloyl glycinamide) (PNAGA), doxorubicin (DOX) loaded and polyester (PE) capped mesoporous silica nanocarriers (MSNs) as well as Fe₃O₄ nanoparticles (Fe₃O₄ NPs) grafted graphene oxide (GO) was fabricated to address above issue. The Fe₃O₄ NPs and GO respectively serve as magnetothermal agent and photothermal agent to perform hyperthermia, meanwhile to generate chain motion of PNAGA with varying degrees under different conditions of magnetic field and/or NIR irradiation. This strategy not only allowed the gel-sol transition of the hydrogel by prior heating for tumor injection, but performed controllable release routes of DOX-MSNs-PE (DMP for short) nanocarriers to meet various requirements from different patients and the changing states of tumor. Furthermore, these escaped DMP nanocarriers could be taken by surrounding tumor cells, and then deliver their drug to these cells after rapid hydrolysis of the PE cap triggered by esterase, resulting in accurate chemotherapy. Both in vitro and in vivo results indicated that the PNAGA-DMP-Fe₃O₄@GO hydrogel combining well-controllable chemotherapy and hyperthermia can eliminate more than 90% tumor cells and effectively inhibit the tumor growth in mice model, demonstrating the great candidate of our hydrogel for accurate tumor therapy.

化学疗法是治疗恶性肿瘤最常用的方法之一。然而，能够精确地操纵局部药物用于按需肿瘤治疗的良好控制的化学疗法仍然是一个挑战。在这里，磁铁和光的双响应水凝胶结合了热敏性聚（N-丙烯酰基甘氨酰胺）（PNAGA），阿霉素（DOX）和聚酯（PE）封端的介孔二氧化硅纳米载体（MSN）以及Fe ₃ O ₄纳米粒子（Fe为了解决上述问题，制造了₃ O ₄ NPs）接枝的氧化石墨烯（GO）。铁₃ O ₄NP和GO分别充当磁热剂和光热剂以执行热疗，同时在不同的磁场和/或NIR照射条件下产生不同程度的PNAGA链运动。该策略不仅允许通过事先加热进行肿瘤注射而使水凝胶发生凝胶-溶胶转变，而且还实现了DOX-MSNs-PE（简称DMP）纳米载体的可控释放途径，以满足不同患者的不同需求以及肿瘤状态的变化。此外，这些逃逸的DMP纳米载体可被周围的肿瘤细胞吸收，然后在酯酶触发的PE帽快速水解后将其药物递送至这些细胞，从而实现准确的化疗。体外和体内结果均表明PNAGA-DMP-Fe₃ O ₄ @GO水凝胶将可控的化学疗法和热疗相结合，可以消除90％以上的肿瘤细胞，并有效抑制小鼠模型中的肿瘤生长，证明我们的水凝胶非常适合用于精确的肿瘤治疗。