Chemotherapy has been a major option in clinic treatment of malignant tumors. However, single chemotherapy faces some drawbacks, such as multidrug resistance, severe side effects, which hinder its clinic application in tumor treatment. Multifunctional nanoparticles loading with chemotherapeutic agent and photosensitizer could be a promising way to efficiently conduct tumor combination therapy. In the current study, a novel pH-sensitive and bubble-generating mesoporous silica-based drug delivery system (denoted as M(a)D@PI-PEG-RGD) was constructed. Ammonium bicarbonate (NH₄HCO₃; abc) and chemotherapeutic agent doxorubicin (DOX) were loaded into the pores of mesoporous silica. Indocyanine green (ICG) as a photothermal and photodynamic agent was loaded onto the polydopamine (PDA) layer surface. The synthesized nanoparticles displayed a narrow polydispersity (PDI) and small particle size as characterized through dynamic light scattering-autosizer analysis. The nanoparticles also showed high targeting efficacy through RGD modification as indicated by cellular uptake and animal studies. DOX release analysis confirmed that the nanoparticles were pH-dependent and that NH₄HCO₃ accelerated drug release. At the same time, the nanoparticles had obvious photothermal and photodynamic effects performed by ICG which restrained tumor growth remarkably. In summary, the multifunctional nanoparticles presented a promising system for combination therapy.

化学疗法已经成为临床治疗恶性肿瘤的主要选择。然而，单一化学疗法面临一些缺点，例如多药耐药性，严重的副作用，这阻碍了其在肿瘤治疗中的临床应用。载有化学治疗剂和光敏剂的多功能纳米颗粒可能是有效进行肿瘤联合治疗的有前途的方法。在当前的研究中，构建了一种新型的pH敏感和产生气泡的中孔二氧化硅基药物递送系统（称为M（a）D @ PI-PEG-RGD）。碳酸氢铵（NH ₄ HCO ₃; abc）和化学治疗剂阿霉素（DOX）装入中孔二氧化硅的孔中。将作为光热和光动力剂的吲哚菁绿（ICG）加载到聚多巴胺（PDA）层表面上。合成的纳米粒子表现出窄的多分散性（PDI）和较小的粒径，通过动态光散射-自动分析仪进行了表征。如细胞摄取和动物研究所示，纳米颗粒还通过RGD修饰显示出高靶向效果。DOX释放分析证实纳米颗粒是pH依赖性的，并且NH ₄ HCO ₃加速药物释放。同时，ICG对纳米颗粒具有明显的光热和光动力作用，明显抑制了肿瘤的生长。总之，多功能纳米颗粒提供了一种有前途的联合治疗系统。