Objective

Cervicocephalic artery dissection (CeAD) is the most common cause of ischemic stroke in young adults. Although the exact cause is unknown, inflammation is thought to have a role. Here, we investigated the relationship between CeAD and inflammation.

Methods

Patients diagnosed with CeAD in our stroke center were evaluated retrospectively, and their demographic and clinical features were recorded. The C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), white blood cell, neutrophil and lymphocyte counts, platelet/lymphocyte ratio (PLR), and neutrophil/lymphocyte ratio (NLR) were recorded on admission. Modified Rankin scores (mRS) were noted on admission and at 6 months to evaluate the dependency status and functional outcome of each patient.

Results

Of the 95 patients in the study, 70 (73.7%) were male, and the mean age was 44.4 ± 9.8 years. Patients with high WBC count, ESR, PLR, and NLR frequently had mRS scores of 3–6 at admission; these differences were significant (p = 0.04, p = 0.02, p = 0.04, and p = 0.02, respectively). At 6 months, patients with high CRP and ESR at admission also had significantly poorer prognoses (p < 0.001, p = 0.002, respectively). PLR and NLR values were higher in patients with mRS of 3–6. But there were no significant differences between the good and poor prognosis groups regarding PLR and NLR (p = 0.22, p = 0.05, respectively).

Conclusion

Inflammation may have a role in the prognosis of CeAD, and inflammatory markers can be evaluated as auxiliary tests for determining prognosis.

中文翻译：

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颈脑动脉夹层的炎性标志物和预后：来自三级医院的中风研究。

目的

颅脑动脉夹层动脉瘤（CeAD）是年轻人缺血性中风的最常见原因。尽管确切原因尚不清楚，但认为炎症起一定作用。在这里，我们调查了CeAD与炎症之间的关系。

方法

回顾性评估在我们的卒中中心被诊断为CeAD的患者，并记录其人口统计学和临床​​特征。入院时记录C反应蛋白（CRP），红细胞沉降率（ESR），白细胞，中性粒细胞和淋巴细胞计数，血小板/淋巴细胞比（PLR）和中性粒细胞/淋巴细胞比（NLR）。入院时和6个月时记录改良的Rankin评分（mRS），以评估每位患者的依赖状态和功能结局。

结果

在研究的95名患者中，有70名（73.7％）是男性，平均年龄为44.4±9.8岁。WBC计数高，ESR，PLR和NLR高的患者入院时mRS分数通常为3–6。这些差异是显着的（分别为p = 0.04，p = 0.02，p = 0.04和p = 0.02）。在6个月时，入院时CRP和ESR高的患者的预后也明显较差（分别为p <0.001，p = 0.002）。mRS为3–6的患者的PLR和NLR值较高。但是，关于PLR和NLR，好和差的预后组之间没有显着差异（分别为p = 0.22，p = 0.05）。

结论

炎症可能与CeAD的预后有关，可以将炎症标志物评估为确定预后的辅助手段。