The human fungal pathogen Candida albicans maintains pathogenic and commensal states primarily through cell wall functions. The echinocandin antifungal drug caspofungin inhibits cell wall synthesis and is widely used in treating disseminated candidiasis. Signaling pathways are critical in coordinating the adaptive response to cell wall damage (CWD). C. albicans executes a robust transcriptional program following caspofungin-induced CWD. A comprehensive analysis of signaling pathways at the transcriptional level facilitates the identification of prospective genes for functional characterization and propels the development of novel antifungal interventions. This review article focuses on the molecular functions and signaling crosstalk of the C. albicans transcription factors Sko1, Rlm1, and Cas5 in caspofungin-induced CWD signaling.

人类真菌病原体白色念珠菌主要通过细胞壁功能维持病原体和共生状态。棘皮菌素抗真菌药卡泊芬净抑制细胞壁合成，并广泛用于治疗传播的念珠菌病。信号通路对于协调对细胞壁损伤（CWD）的适应性反应至关重要。白色念珠菌在卡泊芬净诱导的CWD之后执行强大的转录程序。在转录水平上对信号通路的全面分析，有助于鉴定功能性功能的预期基因，并推动新型抗真菌干预措施的发展。这篇评论文章重点在于白色念珠菌的分子功能和信号串扰 卡泊芬净诱导的CWD信号转导中转录因子Sko1，Rlm1和Cas5。