Purpose

To report on our institutional cohort of patients and review the literature of medulloblastoma patients who developed skull/subdural-based lesions following treatment.

Methods

Following institutional review board (IRB) approval, we retrospectively reviewed the medical records of four children with a history of treated medulloblastoma who developed non-specific skull-based/subdural lesions incidentally found on surveillance imaging.

Results

Biopsies of the lesions proved the pathology to be low grade and included inflammatory myofibroblastic tumor, cortical fibrous defect consistent with fibroma, fibrous tissue, and fibrous dysplasia. The finding of calvarial or subdural fibrous lesions in children following therapy for medulloblastoma was noted in four out of 201 (136 with available follow-up data) medulloblastoma patients seen or discussed in our institution over the past 10 years.

Conclusions

These lesions can grow over time and pose a differential diagnostic challenge with metastatic disease when identified. The skull and subdural space should be scrutinized for secondary lesions on surveillance imaging of patients with medulloblastoma who have received craniospinal irradiation as knowledge of this benign occurrence will assist with management.

中文翻译：

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先前接受过髓母细胞瘤治疗的患者的良性颅骨和硬膜下病变。

目的

报告我们的患者机构队列，并回顾治疗后出现颅底/硬膜下病变的髓母细胞瘤患者的文献。

方法

在获得机构审查委员会（IRB）的批准后，我们​​回顾了4名有治疗过的髓母细胞瘤病史的儿童的病历，这些病史在监视影像中偶然发现了非特异性的颅骨/硬膜下病变。

结果

病变的活检证实其病理学为低度，包括炎症性肌纤维母细胞瘤，与纤维瘤一致的皮质纤维缺损，纤维组织和纤维异常增生。在过去10年中，在我们机构中观察或讨论的201名髓母细胞瘤患者（其中有136例有随访资料）中发现有4名儿童发现了髓母细胞瘤治疗后的颅骨或硬膜下纤维性病变。

结论

这些病变会随着时间的推移而增长，并在鉴定出转移性疾病时对诊断提出不同的挑战。在接受颅骨脊髓照射的髓母细胞瘤患者的监视影像中，应仔细检查颅骨和硬膜下腔是否有继发性病变，因为了解这种良性发生将有助于管理。