The study of physico-chemical properties of vancomycin hydrochloride is an important parameter in the pre-formulation analysis of a drug. Pre-formulation study provides important information for formulation design or support the need for molecular modification. The main objective of pre-formulation is to develop a stable and an effective drug, with a safe dosage. Therefore, properties like specific conductivity, density, viscosity, velocity of sound and specific gravity are determined which further helps in determination of critical micelle concentration (CMC). Other thermodynamic parameters are calculated from CMC like change in entropy, enthalpy and Gibb’s free energy which indicated that formation of micelles is favourable and exothermic in nature. Along with this, thermo-acoustic parameters such as apparent molar volume and apparent molar compressibility have also been determined. These parameters reveal that electrostatic interactions are favourable at lower concentrations of vancomycin hydrochloride whereas hydrophobic interactions are dominant at higher concentrations. All these studies have proven useful in determining the types of interactions occurring in the system. Moreover, a stable concentration of vancomycin hydrochloride can also be determined which may aid in the topical formulation of this drug.

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研究盐酸万古霉素的理化性质，以确定其在制剂开发中的潜在应用

盐酸万古霉素的理化性质研究是药物制剂前分析的重要参数。制剂前研究为制剂设计或支持分子修饰的需求提供了重要信息。预先配制的主要目的是开发一种安全有效剂量的稳定有效的药物。因此，确定诸如比电导率，密度，粘度，声速和比重之类的特性，这进一步有助于确定临界胶束浓度（CMC）。从CMC计算其他热力学参数，例如熵，焓和吉布自由能的变化，这表明胶束的形成是有利的，并且在自然界中是放热的。伴随着这个 还确定了热声参数，例如表观摩尔体积和表观摩尔可压缩性。这些参数表明，在盐酸万古霉素浓度较低时，静电相互作用是有利的，而在较高浓度时，疏水相互作用是主要的。已证明所有这些研究对于确定系统中发生的相互作用的类型都是有用的。此外，还可确定稳定浓度的万古霉素盐酸盐，这可有助于该药物的局部制剂。已证明所有这些研究对于确定系统中发生的相互作用的类型都是有用的。此外，还可确定稳定浓度的万古霉素盐酸盐，这可有助于该药物的局部制剂。已证明所有这些研究对于确定系统中发生的相互作用的类型都是有用的。此外，还可确定稳定浓度的万古霉素盐酸盐，这可有助于该药物的局部制剂。