Fine tuning and optimization of magnetic hyperthermia treatments using versatile trapezoidal driving-field waveforms,Nanoscale Advances

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Fine tuning and optimization of magnetic hyperthermia treatments using versatile trapezoidal driving-field waveforms
Nanoscale Advances ( IF 4.6 ) Pub Date : 2020-09-01 , DOI: 10.1039/d0na00358a
Gabriele Barrera ₁ , Paolo Allia ₁ , Paola Tiberto ₁

Affiliation

Applying trapezoidal driving-field waveforms to activate magnetic nanoparticles optimizes their performance as heat generators in magnetic hyperthermia, with notable advantages with respect to the effects of harmonic magnetic fields of the same frequency and amplitude. A rate equation approach is used to determine the hysteretic properties and the power released by monodisperse and polydisperse magnetite nanoparticles with randomly oriented easy axes subjected to a radio-frequency trapezoidal driving field. The heating ability of the activated nanoparticles is investigated by means of a simple model in which the heat equation is solved in radial geometry with boundary conditions simulating in vivo applications. Changes of the inclination of the trapezoidal waveform's lateral sides are shown to induce controlled changes in the specific loss power generated by the activated nanoparticles. Specific issues typical of the therapeutic practice of hyperthermia, such as the need for fine tuning of the optimal treatment temperature in real time, the possibility of combining sequential treatments at different temperatures, and the ability to substantially reduce the heating transient in a hyperthermia treatment are suitably addressed and overcome by making use of versatile driving fields of a trapezoidal shape.

中文翻译：

使用通用梯形驱动场波形微调和优化磁热疗治疗

应用梯形驱动场波形来激活磁性纳米粒子优化了它们在磁热疗中作为热发生器的性能，在相同频率和幅度的谐波磁场的影响方面具有显着优势。速率方程方法用于确定单分散和多分散磁铁矿纳米粒子在射频梯形驱动场下具有随机取向的易轴的滞后特性和释放的功率。活化纳米粒子的加热能力通过一个简单的模型进行研究，其中热方程在径向几何中求解，边界条件在体内模拟应用程序。梯形波形侧面倾斜度的变化显示出引起由活化纳米粒子产生的比损耗功率的受控变化。热疗治疗实践的典型具体问题，例如需要实时微调最佳治疗温度，在不同温度下组合连续治疗的可能性，以及在热疗治疗中显着减少加热瞬态的能力是通过使用梯形的多功能驱动场适当地解决和克服。

更新日期：2020-10-13

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