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Lissajous scanning magnetic particle imaging as a multifunctional platform for magnetic hyperthermia therapy.
Nanoscale ( IF 5.8 ) Pub Date : 2020-09-01 , DOI: 10.1039/d0nr00604a James Wells 1 , Shailey Twamley , Aparna Sekar , Antje Ludwig , Hendrik Paysen , Olaf Kosch , Frank Wiekhorst
Nanoscale ( IF 5.8 ) Pub Date : 2020-09-01 , DOI: 10.1039/d0nr00604a James Wells 1 , Shailey Twamley , Aparna Sekar , Antje Ludwig , Hendrik Paysen , Olaf Kosch , Frank Wiekhorst
Affiliation
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The use of engineered nanoscale magnetic materials in healthcare and biomedical technologies is rapidly growing. Two examples which have recently attracted significant attention are magnetic particle imaging (MPI) for biological monitoring, and magnetic field hyperthermia (MFH) for cancer therapy. Here for the first time, the capability of a Lissajous scanning MPI device to act as a standalone platform to support the application of MFH cancer treatment is presented. The platform is shown to offer functionalities for nanoparticle localization, focused hyperthermia therapy application, and non-invasive tissue thermometry in one device. Combined, these capabilities have the potential to significantly enhance the accuracy, effectiveness and safety of MFH therapy. Measurements of nanoparticle hyperthermia during protracted exposure to the MPI scanner's 3D imaging field sequence revealed spatially focused heating, with a maximum that is significantly enhanced compared with a simple 1-dimensional sinusoidal excitation. The observed spatial heating behavior is qualitatively described based on a phenomenological model considering torques exerted in the Brownian regime. In vitro cell studies using a human acute monocytic leukemia cell line (THP-1) demonstrated strong suppression of both structural integrity and metabolic activity within 24 h following a 40 min MFH treatment actuated within the Lissajous MPI scanner. Furthermore, reconstructed MPI images of the nanoparticles distributed among the cells, and the temperature-sensitivity of the MPI imaging signal obtained during treatment are demonstrated. In summary, combined Lissajous MPI and MFH technologies are presented; demonstrating for the first time their potential for cancer treatment with maximum effectiveness, and minimal collateral damage to surrounding tissues.
中文翻译：
利萨如扫描磁粉成像作为磁疗的多功能平台。
工程纳米级磁性材料在医疗保健和生物医学技术中的使用正在迅速增长。最近引起人们极大关注的两个例子是用于生物监测的磁粉成像（MPI）和用于癌症治疗的磁场热疗（MFH）。首次在此展示了Lissajous扫描MPI设备充当支持MFH癌症治疗应用的独立平台的功能。该平台已显示可在一台设备中提供纳米颗粒定位，聚焦热疗治疗应用和无创组织体温测定的功能。这些功能相结合，有可能显着提高MFH治疗的准确性，有效性和安全性。在长时间暴露于MPI扫描仪的3D成像场序列期间，对纳米粒子热疗的测量显示了空间聚焦加热，与简单的一维正弦激励相比，其最大值显着增强。基于现象模型对考虑到的布朗状态下施加的扭矩进行定性描述，对观察到的空间加热行为进行定性描述。使用人急性单核细胞白血病细胞系（THP-1）进行的体外细胞研究显示，在利萨如MPI扫描仪中启动40分钟MFH处理后，在24小时内对结构完整性和代谢活性的强烈抑制作用。此外，展示了在细胞中分布的纳米颗粒的重建的MPI图像，以及在治疗期间获得的MPI成像信号的温度敏感性。综上所述，结合了Lissajous MPI和MFH技术。首次展示了它们具有最大的疗效，并且对周围组织的附带损害最小的癌症治疗潜力。
更新日期：2020-09-18
中文翻译：
利萨如扫描磁粉成像作为磁疗的多功能平台。
工程纳米级磁性材料在医疗保健和生物医学技术中的使用正在迅速增长。最近引起人们极大关注的两个例子是用于生物监测的磁粉成像（MPI）和用于癌症治疗的磁场热疗（MFH）。首次在此展示了Lissajous扫描MPI设备充当支持MFH癌症治疗应用的独立平台的功能。该平台已显示可在一台设备中提供纳米颗粒定位，聚焦热疗治疗应用和无创组织体温测定的功能。这些功能相结合，有可能显着提高MFH治疗的准确性，有效性和安全性。在长时间暴露于MPI扫描仪的3D成像场序列期间，对纳米粒子热疗的测量显示了空间聚焦加热，与简单的一维正弦激励相比，其最大值显着增强。基于现象模型对考虑到的布朗状态下施加的扭矩进行定性描述，对观察到的空间加热行为进行定性描述。使用人急性单核细胞白血病细胞系（THP-1）进行的体外细胞研究显示，在利萨如MPI扫描仪中启动40分钟MFH处理后，在24小时内对结构完整性和代谢活性的强烈抑制作用。此外，展示了在细胞中分布的纳米颗粒的重建的MPI图像，以及在治疗期间获得的MPI成像信号的温度敏感性。综上所述，结合了Lissajous MPI和MFH技术。首次展示了它们具有最大的疗效，并且对周围组织的附带损害最小的癌症治疗潜力。
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