Glucose monitoring is an important clinical procedure, especially for dialysis patients who need consistent monitoring of their glucose levels. Currently, the most extensively used method for glucose monitoring involves pricking the finger and sampling a small amount of blood. Given that this procedure is inconvenient and can cause pain and potential infection, there is demand for the development of alternative glucose sensing methods. This study introduces a methodology for improved glucose sensor specificity based on a calibration scheme. One microwave and one capacitive glucose sensor were designed and placed on a prosthetic vascular graft. Each sensor yielded a finite variation in the measured glucose concentrations based on its capacity to sense permittivity changes in aqueous D-glucose solutions. However, as blood components other than glucose—such as proteins, erythrocytes and haemoglobin—may affect the measurements, the authors also introduced a calibration scheme to adjust and calibrate each measurement to ensure accuracy. The measurement data yielded a maximum error of <7.33%. Based on these outcomes, the specificity of glucose monitoring in prosthetic vascular grafts is validated.

中文翻译：

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基于校准方案改善人工血管移植物的双葡萄糖传感器特异性

葡萄糖监测是重要的临床程序，特别是对于需要持续监测其葡萄糖水平的透析患者。当前，用于血糖监测的最广泛使用的方法包括刺破手指并采样少量血液。鉴于该过程不方便并且会引起疼痛和潜在的感染，因此需要开发替代的葡萄糖感测方法。这项研究介绍了一种基于校准方案的改进葡萄糖传感器特异性的方法。设计了一个微波和一个电容性葡萄糖传感器，并将其放置在人工血管上。每个传感器根据其感测D-葡萄糖水溶液中介电常数变化的能力，在测得的葡萄糖浓度上产生有限的变化。然而，由于葡萄糖以外的血液成分（例如蛋白质，红细胞和血红蛋白）可能会影响测量，因此作者还引入了一种校准方案来调整和校准每个测量，以确保准确性。测量数据产生的最大误差<7.33％。基于这些结果，验证了人造血管移植物中葡萄糖监测的特异性。