Nanotechnology-based drug delivery systems for enhanced diagnosis and therapy of oral cancer,Journal of Materials Chemistry B

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Nanotechnology-based drug delivery systems for enhanced diagnosis and therapy of oral cancer
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-09-01 , DOI: 10.1039/d0tb00957a
Zhangfan Ding _{1,

2,

3,

4,

5} , Krishna Sigdel _{1,

2,

3,

4,

5} , Lei Yang _{5,

6,

7,

8} , Yunfei Liu _{5,

9,

10} , Ming Xuan _{1,

2,

3,

4,

5} , Xiaoyi Wang _{1,

2,

3,

4,

5} , Zhipeng Gu _{5,

6,

7,

8} , Jun Wu _{5,

11,

12,

13} , Huixu Xie _{1,

2,

3,

4,

5}

Affiliation

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Head and Neck Oncology Surgery
West China Hospital of Stomatology
Sichuan University
Chengdu 610041
P. R. China
College of Polymer Science and Engineering
State Key Laboratory of Polymer Materials Engineering, Sichuan University
Chengdu 610065
Stomatological Hospital of Chongqing Medical University & Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences & Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education
Chongqing 401147
Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, School of Biomedical Engineering
Sun Yat-sen University
Guangzhou 510006

Oral cancer is a common malignant life-threatening tumor. Despite some advances in traditional therapy, mortality and mobidity rates are high due to delayed diagnosis and ineffective treatment. Additionally, some patients inevitably suffer from various fatal adverse effects during the course of therapy. Therefore, it is imperative to develop novel methods to eradicate oral cancer cells with minimal adverse effects on normal cells. Nanotechnology is a promising and novel vehicle for the diagnosis and treatment of oral cancer with encouraging recent achievements. In this review, we present state-of-the-art nanotechnology-based drug delivery systems employed in the domain of oral cancer, especially for its enhanced diagnosis and therapy. We describe in detail the types of nanotechnology used in the management of oral cancer and summarize administration routes of nanodrugs. Finally, the potential and prospects of nanotechnology-based drug delivery systems as promising modalities of diagnosis and therapy of oral cancer are highlighted.

中文翻译：

基于纳米技术的药物输送系统，可增强口腔癌的诊断和治疗

口腔癌是一种常见的威胁生命的恶性肿瘤。尽管传统疗法取得了一些进展，但由于诊断延迟和治疗无效，死亡率和发病率仍然很高。另外，一些患者在治疗过程中不可避免地遭受各种致命的不利影响。因此，迫切需要开发新的方法来根除口腔癌细胞，而对正常细胞的不良影响则最小。纳米技术是一种令人鼓舞的新颖工具，可用于口腔癌的诊断和治疗，并取得了令人鼓舞的最新成果。在这篇综述中，我们介绍了在口腔癌领域中采用的基于纳米技术的最新技术，尤其是其增强的诊断和治疗能力。我们详细描述了用于口腔癌治疗的纳米技术的类型，并总结了纳米药物的给药途径。最后，强调了基于纳米技术的药物递送系统作为口腔癌的诊断和治疗的有前途的方式的潜力和前景。

更新日期：2020-10-07

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