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Applications of nanomaterials for scavenging reactive oxygen species in the treatment of central nervous system diseases.
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-09-01 , DOI: 10.1039/d0tb01380c Zhen An 1 , Jincong Yan 2 , Ye Zhang 2 , Renjun Pei 1
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-09-01 , DOI: 10.1039/d0tb01380c Zhen An 1 , Jincong Yan 2 , Ye Zhang 2 , Renjun Pei 1
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Reactive oxygen species (ROS) are the key signaling molecules in many physiological processes and play an important role in the development and function of the central nervous system (CNS). However, the process of CNS diseases is often accompanied by excessive production of ROS, which will induce oxidative stress, aggravate the pathological changes of the diseases, and cause neuroinflammation and loss of neurons. Therefore, it is beneficial for the treatment of CNS diseases and the recovery of the nerve function to eliminate the excessive ROS formed during the pathological changes of the CNS. Although several antioxidants have been proved to restore redox balance, their disappointing clinical performance has predicted less optimistic prospects in antioxidant therapy for ROS-associated CNS diseases. In recent years, nanomaterials with ROS-scavenging ability have been considered as promising substances to alleviate oxidative stress in CNS diseases because of their excellent ROS scavenging effect and biodistribution. This review article aims to elucidate the ROS scavenging mechanisms of various nanomaterials, introduce the reasons for ROS generation in CNS diseases, and review the applications of nanomaterials in scavenging ROS in CNS diseases reported in recent years.
中文翻译：
纳米材料在治疗中枢神经系统疾病中清除活性氧的应用。
活性氧（ROS）是许多生理过程中的关键信号分子，在中枢神经系统（CNS）的发育和功能中起重要作用。然而，CNS疾病的过程通常伴随着过量的ROS的产生，其将引起氧化应激，加剧疾病的病理变化，并引起神经炎症和神经元的丧失。因此，消除CNS的病理变化过程中形成的过量ROS对于CNS疾病的治疗和神经功能的恢复是有益的。尽管已经证明了几种抗氧化剂可以恢复氧化还原平衡，但是其令人失望的临床表现预示了与ROS相关的中枢神经系统疾病的抗氧化剂治疗的乐观前景不大。最近几年，具有ROS清除能力的纳米材料因其出色的ROS清除效果和生物分布特性，被认为是缓解CNS疾病氧化应激的有前途的物质。这篇综述文章旨在阐明各种纳米材料的ROS清除机理，介绍中枢神经系统疾病中产生ROS的原因，并综述近年来报道的纳米材料在中枢神经系统疾病中清除ROS的应用。
更新日期：2020-10-07
中文翻译：
纳米材料在治疗中枢神经系统疾病中清除活性氧的应用。
活性氧（ROS）是许多生理过程中的关键信号分子，在中枢神经系统（CNS）的发育和功能中起重要作用。然而，CNS疾病的过程通常伴随着过量的ROS的产生，其将引起氧化应激，加剧疾病的病理变化，并引起神经炎症和神经元的丧失。因此，消除CNS的病理变化过程中形成的过量ROS对于CNS疾病的治疗和神经功能的恢复是有益的。尽管已经证明了几种抗氧化剂可以恢复氧化还原平衡，但是其令人失望的临床表现预示了与ROS相关的中枢神经系统疾病的抗氧化剂治疗的乐观前景不大。最近几年，具有ROS清除能力的纳米材料因其出色的ROS清除效果和生物分布特性，被认为是缓解CNS疾病氧化应激的有前途的物质。这篇综述文章旨在阐明各种纳米材料的ROS清除机理，介绍中枢神经系统疾病中产生ROS的原因，并综述近年来报道的纳米材料在中枢神经系统疾病中清除ROS的应用。
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