Sulfoximines as Rising Stars in Modern Drug Discovery? Current Status and Perspective on an Emerging Functional Group in Medicinal Chemistry.,Journal of Medicinal Chemistry

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Sulfoximines as Rising Stars in Modern Drug Discovery? Current Status and Perspective on an Emerging Functional Group in Medicinal Chemistry.
Journal of Medicinal Chemistry ( IF 6.8 ) Pub Date : 2020-09-01 , DOI: 10.1021/acs.jmedchem.0c00960
Patrick Mäder ₁ , Lars Kattner ₁

Affiliation

Sulfoximines have been largely disregarded in medicinal chemistry for a long time. However, recently, they have risen to the apparent level of stardom on the drug discovery scene. Considering the outstanding properties of sulfoximines, this versatile functional group has advanced to implementation in several drug discovery programs. Currently, this fashionable functional group can be found in various hit-to-lead and lead optimization studies in early stages and in several compounds currently in clinical trials. Herein, we review recent developments to demonstrate the scope and limitations of this interesting and versatile functional group in medicinal chemistry and drug discovery.

中文翻译：

磺胺嘧啶是现代药物发现中的后起之秀？药物化学中新兴官能团的现状与展望。

长期以来，磺胺嘧啶一直在药物化学中被忽视。然而，最近，它们在药物发现领域已上升到明显的明星水平。考虑到亚砜肟类的卓越性能，该多功能官能团已在多种药物发现计划中得以推广。当前，这个时尚的官能团可以在早期的各种铅对铅和铅优化研究中以及在临床试验中的几种化合物中找到。本文中，我们回顾了最近的发展，以证明这一有趣且用途广泛的官能团在药物化学和药物发现中的范围和局限性。

更新日期：2020-09-01

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