Background. The white blood cell count to mean platelet volume ratio (WMR) is an indicator of inflammation in patients with atherosclerotic disease. Residual SYNTAX Score (RSS) is an objective measure of degree and complexity of residual stenosis after percutaneous coronary intervention (PCI). We investigated the relationship between WMR and clinical prognosis and RSS in patients undergoing primary percutaneous coronary intervention (P-PCI). Method. Between June 2015 and December 2018, 537 patients who underwent primary PCI were evaluated for in-hospital events, and 477 patients were evaluated for clinical events during follow-up after discharge. The endpoint of our study is major adverse cardiac events (MACEs) seen in the in-hospital and follow-up periods. Results. In our study, 537 patients were stratified into two groups according to admission median WMR. There were 268 patients in the low WMR group () and 269 patients in the high WMR group (). RSS () value of the high WMR group was higher than that of the low WMR group. The rates of in-hospital MACE (), cardiac death (), decompansated heart failure (0.007), and ventricular tachycardia/fibrillation () were higher in the high WMR group than in the low WMR group. The follow-up MACEs (), cardiac death (), and reinfarction () ratio were higher in the high WMR group. In ROC analysis, cut-off values of in-hospital and follow-up MACEs were >1064 (sensitivity: 83.12%, and specificity: 36.29%) and >1130 (sensitivity: 69.15%, and specificity: 44.91%), respectively. The Kaplan-Meier analysis showed that the high WMR group had the significantly lowest MACE-free survival rate (log-rank test, ). A moderate correlation was observed between WMR and RSS (: 456, ). Conclusion. A higher WMR value on admission was associated with worse outcomes in patients with P-PCI and independently predicted for follow-up MACEs. The WMR provides both a rapid and an easily obtainable parameter to identify reliably high-risk patients who underwent primary percutaneous coronary intervention due to STEMI.

中文翻译：

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接受初次经皮冠状动脉介入治疗的患者白细胞计数与平均血小板体积比与冠状动脉疾病临床结果和严重程度的关系。

背景。白细胞计数与平均血小板体积比 (WMR) 是动脉粥样硬化疾病患者炎症的指标。残余 SYNTAX 评分 (RSS) 是经皮冠状动脉介入治疗 (PCI) 后残余狭窄程度和复杂性的客观衡量标准。我们调查了接受初次经皮冠状动脉介入治疗 (P-PCI) 患者的 WMR 与临床预后和 RSS 之间的关系。方法。2015 年 6 月至 2018 年 12 月期间，537 名接受直接 PCI 的患者接受了院内事件评估，477 名患者在出院后的随访期间接受了临床事件评估。我们研究的终点是在住院期间和随访期间出现的主要不良心脏事件 (MACE)。结果. 在我们的研究中，根据入院中位 WMR 将 537 名患者分为两组。低 WMR 组有 268 例患者（)和高 WMR 组的 269 名患者 (）。RSS ()高 WMR 组的值高于低 WMR 组。院内 MACE 发生率 (),心源性死亡 ()、失代偿性心力衰竭 (0.007) 和室性心动过速/纤颤 ()在高 WMR 组中高于低 WMR 组。后续 MACE (),心源性死亡 ()和再梗死 ()比率在高 WMR 组中更高。在 ROC 分析中，住院和随访 MACE 的临界值分别为 >1064（敏感性：83.12%，特异性：36.29%）和 >1130（敏感性：69.15%，特异性：44.91%）。Kaplan-Meier 分析显示，高 WMR 组的无 MACE 存活率显着最低（对数秩检验，）。在 WMR 和 RSS 之间观察到中等相关性 ( : 456,）。 结论。入院时较高的 WMR 值与 P-PCI 患者的较差结果相关，并且独立预测后续 MACE。WMR 提供了一个快速且易于获得的参数，以可靠地识别因 STEMI 接受初次经皮冠状动脉介入治疗的高危患者。