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A database of flavivirus RNA structures with a search algorithm for pseudoknots and triple base interactions.
Bioinformatics ( IF 4.4 ) Pub Date : 2020-08-31 , DOI: 10.1093/bioinformatics/btaa759
Alan Zammit 1 , Leon Helwerda 1 , René C L Olsthoorn 2 , Fons J Verbeek 1 , Alexander P Gultyaev 1, 3
Affiliation  

The Flavivirus genus includes several important pathogens such as Zika, dengue and yellow fever virus. Flavivirus RNA genomes contain a number of functionally important structures in their 3' untranslated regions (3'UTRs). Due to the diversity of sequences and topologies of these structures, their identification is often difficult. On the other hand, predictions of such structures is important for understanding of flavivirus replication cycles and development of antiviral strategies.

中文翻译:

黄病毒 RNA 结构数据库,具有用于假结和三碱基相互作用的搜索算法。

黄病毒属包括几种重要的病原体,例如寨卡病毒、登革热病毒和黄热病病毒。黄病毒 RNA 基因组在其 3' 非翻译区 (3'UTR) 中包含许多功能上重要的结构。由于这些结构的序列和拓扑结构的多样性,它们的识别通常很困难。另一方面,对这种结构的预测对于理解黄病毒复制周期和制定抗病毒策略很重要。
更新日期:2020-09-01
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