Silicone hydrogel contact lenses (CLs) permit increased oxygen permeability through their incorporation of siloxane functional groups. However, contact lens biofouling can be problematic with these materials; surface modification to increase lens compatibility is necessary for acceptable properties. This work focuses on the creation of an antifouling CL surface through a novel grafting method. A polymer incorporating 2-methacryloyloxyethyl phosphorylcholine (MPC), well known for its antifouling and biomimetic properties, was grafted to the model lens surfaces using surface-initiated atom transfer radical polymerization (SI-ATRP). The SI-ATRP modification generated a unique double-grafted polymeric architecture designed to resist protein adsorption through the presence of a surrounding hydration layer due to the PC groups and steric repulsion due to the density of the grafted chains. The polymer was grafted from model silicone hydrogel CL using a four-step SI-ATRP process. Attenuated total reflectance-Fourier transform infrared spectroscopy and XPS were used to confirm the surface chemical composition at each step of the synthesis. Both the surface wettability and equilibrium water content of the materials increased significantly upon polyMPC modification. The surface water contact angle was as low as 16.04 ± 2.37° for polyMPC-50 surfaces; complete wetting (∼0°) was observed for polyMPC-100 surfaces. A decrease in the protein adsorption by as much as 83% (p < 0.000 36) for lysozyme and 73% (p < 0.0076) for bovine serum albumin was observed, with no significant difference between different polyMPC chain lengths. The data demonstrate the potential of this novel modification process for the creation of extremely wettable and superior antifouling surfaces, useful for silicone hydrogel CL surfaces.

中文翻译：

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通过密集接枝的磷酰胆碱聚合物防污硅水凝胶隐形眼镜。

有机硅水凝胶隐形眼镜 (CL) 通过掺入硅氧烷官能团来增加透氧性。然而，隐形眼镜的生物污染可能会成为这些材料的问题；表面改性以增加镜片兼容性对于可接受的性能是必要的。这项工作的重点是通过一种新的接枝方法创建防污 CL 表面。使用表面引发的原子转移自由基聚合 (SI-ATRP) 将含有 2-甲基丙烯酰氧乙基磷酰胆碱 (MPC) 的聚合物接枝到模型镜片表面，该聚合物以其防污和仿生特性而闻名。SI-ATRP 修饰产生了一种独特的双接枝聚合物结构，旨在通过周围水化层的存在来抵抗蛋白质吸附，这是由于 PC 基团和由于接枝链密度造成的空间排斥。使用四步 SI-ATRP 工艺从模型硅水凝胶 CL 接枝聚合物。衰减全反射-傅立叶变换红外光谱和 XPS 用于确认合成的每个步骤中的表面化学成分。PolyMPC 改性后材料的表面润湿性和平衡水含量均显着增加。polyMPC-50 表面的表面水接触角低至 16.04 ± 2.37°；观察到 polyMPC-100 表面完全润湿（~0°）。蛋白质吸附减少多达 83% (p < 0. 000 36) 溶菌酶和 73% (p < 0.0076) 的牛血清白蛋白被观察到，不同的 polyMPC 链长度之间没有显着差异。数据证明了这种新型改性工艺在创造极其润湿和优异的防污表面方面的潜力，可用于硅水凝胶 CL 表面。