Cefiderocol is a siderophore cephalosporin active against many multidrug-resistant (MDR) Gram-negative pathogens. We examined the resistance mechanisms in 12 Acinetobacter baumannii strains with cefiderocol MICs ranging from ≤0.03 to >32 μg/ml. Cefiderocol resistance could not be explained by β-lactamase activity. Cefiderocol resistance was associated with reduced expression of the siderophore receptor gene pirA. Mutations involving PBP3 may have contributed to resistance in one strain. Additional studies are needed to assess the role of other siderophore receptors.

中文翻译：

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鲍曼不动杆菌中的头孢地罗耐药性：β-内酰胺酶、铁载体受体和青霉素结合蛋白 3 的作用。


头孢地考是一种铁载体头孢菌素，对许多多重耐药 (MDR) 革兰氏阴性病原体具有活性。我们检查了 12 种鲍曼不动杆菌菌株的耐药机制，头孢地罗的 MIC 范围为 ≤0.03 至 >32 μg/ml。头孢地罗耐药不能用β-内酰胺酶活性来解释。头孢地考耐药性与铁载体受体基因pirA表达减少有关。涉及 PBP3 的突变可能导致一种菌株产生耐药性。需要进行更多研究来评估其他铁载体受体的作用。