Cholinergic transmission in C. elegans: Functions, diversity, and maturation of ACh-activated ion channels,Journal of Neurochemistry

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Cholinergic transmission in C. elegans: Functions, diversity, and maturation of ACh-activated ion channels
Journal of Neurochemistry ( IF 4.2 ) Pub Date : 2020-08-31 , DOI: 10.1111/jnc.15164
Millet Treinin ₁ , Yishi Jin ₂

Affiliation

Acetylcholine is an abundant neurotransmitter in all animals. Effects of acetylcholine are excitatory, inhibitory, or modulatory depending on the receptor and cell type. Research using the nematode C. elegans has made ground-breaking contributions to the mechanistic understanding of cholinergic transmission. Powerful genetic screens for behavioral mutants or for responses to pharmacological reagents identified the core cellular machinery for synaptic transmission. Pharmacological reagents that perturb acetylcholine-mediated processes led to the discovery and also uncovered the composition and regulators of acetylcholine-activated channels and receptors. From a combination of electrophysiological and molecular cellular studies, we have gained a profound understanding of cholinergic signaling at the levels of synapses, neural circuits, and animal behaviors. This review will begin with a historical overview, then cover in-depth current knowledge on acetylcholine-activated ionotropic receptors, mechanisms regulating their functional expression and their functions in regulating locomotion.

中文翻译：

秀丽隐杆线虫中的胆碱能传递：乙酰胆碱激活离子通道的功能、多样性和成熟

乙酰胆碱是所有动物体内丰富的神经递质。取决于受体和细胞类型，乙酰胆碱的作用是兴奋性、抑制性或调节性。研究使用线虫Ç。线虫对胆碱能传递的机制理解做出了开创性的贡献。针对行为突变体或对药理试剂反应的强大遗传筛选确定了突触传递的核心细胞机制。扰乱乙酰胆碱介导的过程的药理学试剂导致了这一发现，并揭示了乙酰胆碱激活通道和受体的组成和调节剂。通过结合电生理学和分子细胞研究，我们对突触、神经回路和动物行为水平的胆碱能信号有了深刻的了解。本综述将从历史概述开始，然后涵盖有关乙酰胆碱激活的离子型受体的深入当前知识，

更新日期：2020-08-31

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