Localized singlet-filtered MRS in vivo.,NMR in Biomedicine

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Localized singlet-filtered MRS in vivo.
NMR in Biomedicine ( IF 2.7 ) Pub Date : 2020-09-01 , DOI: 10.1002/nbm.4400
Salvatore Mamone _{1,

2} , Andreas B Schmidt _{3,

4,

5} , Niels Schwaderlapp ₃ , Thomas Lange ₃ , Dominik von Elverfeldt ₃ , Jürgen Hennig ₃ , Stefan Glöggler _{1,

2}

Affiliation

MR is a prominent technology to investigate diseases, with millions of clinical procedures performed every year. Metabolic dysfunction is one common aspect associated with many diseases. Thus, understanding and monitoring metabolic changes is essential to develop cures for many illnesses, including for example cancer and neurodegeneration. MR methodologies are especially suited to study endogenous metabolites and processes within an organism in vivo, which has led to many insights about physiological functions. Advancing metabolic MR techniques is therefore key to further understand physiological processes. Here, we introduce an approach based on nuclear spin singlet states to specifically filter metabolic signals and particularly show that singlet‐filtered glutamate can be observed distinctly in the hippocampus of a living mouse in vivo. This development opens opportunities to make use of the singlet spin phenomenon in vivo and besides its use as a filter to provide scope for new contrast agents.

中文翻译：

体内局部单线态过滤 MRS。

MR 是一种研究疾病的重要技术，每年执行数百万次临床手术。代谢功能障碍是与许多疾病相关的常见方面之一。因此，了解和监测代谢变化对于开发许多疾病的治疗方法至关重要，包括癌症和神经退行性疾病。 MR 方法特别适合研究体内生物体的内源代谢物和过程，这带来了许多关于生理功能的见解。因此，推进代谢磁共振技术是进一步了解生理过程的关键。在这里，我们介绍了一种基于核自旋单线态的方法来特异性过滤代谢信号，并特别表明可以在活体小鼠体内的海马体中清楚地观察到单线态过滤的谷氨酸。这一发展为利用体内单线态自旋现象提供了机会，并且除了将其用作过滤器之外，还为新的造影剂提供了范围。

更新日期：2020-09-01

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