Brain-derived neurotrophic factor is elevated in the blood serum of Crohn's disease patients, but is not influenced by anti-TNF-α treatment—A pilot study,Neurogastroenterology & Motility

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Brain-derived neurotrophic factor is elevated in the blood serum of Crohn's disease patients, but is not influenced by anti-TNF-α treatment—A pilot study
Neurogastroenterology & Motility ( IF 3.5 ) Pub Date : 2020-08-31 , DOI: 10.1111/nmo.13978
Marcin Sochal ₁ , Ewa Małecka-Panas ₂ , Agata Gabryelska ₁ , Jakub Fichna ₃ , Renata Talar-Wojnarowska ₂ , Bartosz Szmyd ₁ , Piotr Białasiewicz ₁

Affiliation

Brain-derived neurotrophic factor (BDNF) is associated with depression, pain, or sleep disorders, factors that are thought to be involved in the pathogenesis and clinical course of Crohn's disease (CD). Therefore, the study aimed at assessing the BDNF serum level in patients with CD and evaluates the effect of anti-TNF-α therapy on the BDNF level and its impact on sleep, mood, and pain parameters.

中文翻译：

克罗恩病患者血清中脑源性神经营养因子升高，但不受抗 TNF-α 治疗的影响——一项初步研究

脑源性神经营养因子 (BDNF) 与抑郁、疼痛或睡眠障碍有关，这些因素被认为与克罗恩病 (CD) 的发病机制和临床过程有关。因此，该研究旨在评估 CD 患者的 BDNF 血清水平，并评估抗 TNF-α 治疗对 BDNF 水平的影响及其对睡眠、情绪和疼痛参数的影响。

更新日期：2020-08-31

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