BACKGROUND Favism is an acute hemolytic syndrome caused by fava bean (FB) ingestion. The purpose of this study was to investigate the possible influences of FB on the metabonomic profile of erythrocytes in glucose-6-phosphate dehydrogenase (G6PD)-deficient (G6PDx) and wild type (WT) mice. RESULTS Ninety-two metabolites were identified in the comparison of the G6PDx with WT groups. Eighty-seven metabolites were identified in the erythrocytes of WT and G6PDx mice after FB ingestion. Thirty-eight metabolites were identified in the comparison of the FB-treated G6PDx with FB-treated WT mouse groups. Among them, number of glycerophospholipids (GPLs) and polyunsaturated fatty acids (PUFAs) were significantly changed, which suggests that GPLs and PUFAs may be responsible for FB stress. CONCLUSION This study demonstrates that G6PD deficiency might affect the metabonomic profile of erythrocytes in response to FB. This article is protected by copyright. All rights reserved.

中文翻译：

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代谢分析揭示了 G6PD 缺陷小鼠红细胞对蚕豆摄入反应的改变

背景蚕豆病是一种由蚕豆（FB）摄入引起的急性溶血综合征。本研究的目的是研究 FB 对葡萄糖 6-磷酸脱氢酶 (G6PD) 缺陷型 (G6PDx) 和野生型 (WT) 小鼠红细胞代谢组学特征的可能影响。结果 在 G6PDx 与 WT 组的比较中鉴定了 92 种代谢物。在摄入 FB 后，在 WT 和 G6PDx 小鼠的红细胞中鉴定出 87 种代谢物。在 FB 处理的 G6PDx 与 FB 处理的 WT 小鼠组的比较中鉴定了 38 种代谢物。其中，甘油磷脂（GPLs）和多不饱和脂肪酸（PUFAs）的数量发生了显着变化，这表明GPLs和PUFAs可能是FB应激的原因。结论 本研究表明，G6PD 缺乏可能会影响红细胞对 FB 的代谢特征。本文受版权保护。版权所有。