Guillain‐Barré syndrome (GBS) is an immune‐mediated polyradiculoneuropathy frequently preceded by an infection with Campylobacter jejuni or nonspecific infections, and rarely by a vaccination. Due to a lack of a pathognomonic finding or biomarker, its diagnosis is based on a typical constellation of clinical and paraclinical symptoms and findings. The Brighton Collaboration GBS Working Group published in 2011 GBS case definitions and guidelines for diagnosis to improve the registration of GBS cases occurring in conjunction with vaccination programs worldwide. We applied these criteria to two historical studies on GBS in children and adolescents performed retrospectively from 1989 to 1994 and prospectively from 1998 to 2002. The clinical criteria were met in 91% of the retrospective and all of the prospective cases. CSF investigations were conducted in all patients and revealed cytoalbuminologic dissociation in 80% of the retrospective and 75% of the prospective cohort. Nerve conduction studies were performed in 61% and 69% of the cohorts, respectively, and were pathological in 92% each. The Brighton criteria are well suited to capture GBS in retro‐ and prospective studies. However, because they are designed to diagnose classical symmetric and ascending GBS and Fisher syndrome, very rare topographical variants of GBS such as the pharyngo‐cervico‐brachial variant and others could be missed.

中文翻译：

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Brighton Collaboration 案例定义：对格林-巴利综合征儿童回顾性和前瞻性队列的比较。

吉兰-巴雷综合征 (GBS) 是一种免疫介导的多发性神经根神经病，之前经常感染空肠弯曲杆菌或非特异性感染，很少通过疫苗接种。由于缺乏特征性发现或生物标志物，其诊断基于一系列典型的临床和副临床症状和发现。布莱顿协作 GBS 工作组于 2011 年发布了 GBS 病例定义和诊断指南，以改进与全球疫苗接种计划相关的 GBS 病例的登记。我们将这些标准应用于 1989 年至 1994 年回顾性和 1998 年至 2002 年前瞻性进行的两项关于儿童和青少年 GBS 的历史研究。91% 的回顾性病例和所有前瞻性病例符合临床标准。对所有患者进行了脑脊液检查，发现在 80% 的回顾性和 75% 的前瞻性队列中细胞白蛋白分离。分别在 61% 和 69% 的队列中进行了神经传导研究，并且各有 92% 是病理性的。Brighton 标准非常适合在回顾性和前瞻性研究中捕获 GBS。然而，由于它们旨在诊断经典对称和上行 GBS 和 Fisher 综合征，因此可能会遗漏非常罕见的 GBS 地形变异，例如咽-颈-臂变异等。