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Quantitative and qualitative alterations of circulating myeloid cells and plasmacytoid DC in SARS-CoV-2 infection.
Immunology ( IF 4.9 ) Pub Date : 2020-09-01 , DOI: 10.1111/imm.13254 Benedetta Peruzzi 1 , Sara Bencini 1 , Manuela Capone 2 , Alessio Mazzoni 2 , Laura Maggi 2 , Lorenzo Salvati 2 , Anna Vanni 2 , Chiara Orazzini 1 , Carlo Nozzoli 3 , Alessandro Morettini 4 , Loredana Poggesi 2, 5 , Filippo Pieralli 6 , Adriano Peris 7 , Alessandro Bartoloni 2, 8 , Alessandro Maria Vannucchi 2, 9 , Francesco Liotta 2, 10 , Roberto Caporale 1 , Lorenzo Cosmi 2, 10 , Francesco Annunziato 1, 2
Immunology ( IF 4.9 ) Pub Date : 2020-09-01 , DOI: 10.1111/imm.13254 Benedetta Peruzzi 1 , Sara Bencini 1 , Manuela Capone 2 , Alessio Mazzoni 2 , Laura Maggi 2 , Lorenzo Salvati 2 , Anna Vanni 2 , Chiara Orazzini 1 , Carlo Nozzoli 3 , Alessandro Morettini 4 , Loredana Poggesi 2, 5 , Filippo Pieralli 6 , Adriano Peris 7 , Alessandro Bartoloni 2, 8 , Alessandro Maria Vannucchi 2, 9 , Francesco Liotta 2, 10 , Roberto Caporale 1 , Lorenzo Cosmi 2, 10 , Francesco Annunziato 1, 2
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SARS‐CoV‐2 is responsible for a new infectious disease (COVID‐19) in which individuals can either remain asymptomatic or progress from mild to severe clinical conditions including acute respiratory distress syndrome and multiple organ failure. The immune mechanisms that potentially orchestrate the pathology in SARS‐CoV‐2 infection are complex and only partially understood. There is still paucity of data on the features of myeloid cells involved in this viral infection. For this reason, we investigated the different activation status profiles and the subset distribution of myeloid cells and their correlation with disease progression in 40 COVID‐19 patients at different stages of disease. COVID‐19 patients showed a decrease in the absolute number of plasmacytoid and myeloid dendritic cells, different subset distribution of monocytes and different activation patterns of both monocytes and neutrophils, coupled to a significant reduction of HLA‐DR monocyte levels. We found that some of these alterations are typical of all COVID‐19 patients, while some others vary at different stages of the disease and correlate with biochemical parameters of inflammation. Collectively, these data suggest that not only the lymphoid, but also the myeloid compartment, is severely affected by SARS‐CoV‐2 infection.
中文翻译：
SARS-CoV-2 感染中循环骨髓细胞和浆细胞样 DC 的定量和定性变化。
SARS-CoV-2 是一种新的传染病 (COVID-19)，在这种疾病中，个体可以保持无症状，也可以从轻度发展为严重的临床症状，包括急性呼吸窘迫综合征和多器官衰竭。可能协调 SARS-CoV-2 感染病理学的免疫机制很复杂，而且人们对它的了解还很有限。关于这种病毒感染所涉及的骨髓细胞特征的数据仍然很少。为此，我们研究了 40 名处于不同疾病阶段的 COVID-19 患者的不同激活状态谱和骨髓细胞亚群分布及其与疾病进展的相关性。COVID-19患者表现出浆细胞样和髓样树突细胞绝对数量减少、单核细胞亚群分布不同以及单核细胞和中性粒细胞激活模式不同，同时HLA-DR单核细胞水平显着降低。我们发现，其中一些改变是所有 COVID-19 患者的典型改变，而另一些改变在疾病的不同阶段有所不同，并与炎症的生化参数相关。总的来说，这些数据表明，不仅淋巴系统，而且骨髓室也受到 SARS-CoV-2 感染的严重影响。
更新日期：2020-09-01
中文翻译：
SARS-CoV-2 感染中循环骨髓细胞和浆细胞样 DC 的定量和定性变化。
SARS-CoV-2 是一种新的传染病 (COVID-19)，在这种疾病中，个体可以保持无症状，也可以从轻度发展为严重的临床症状，包括急性呼吸窘迫综合征和多器官衰竭。可能协调 SARS-CoV-2 感染病理学的免疫机制很复杂，而且人们对它的了解还很有限。关于这种病毒感染所涉及的骨髓细胞特征的数据仍然很少。为此，我们研究了 40 名处于不同疾病阶段的 COVID-19 患者的不同激活状态谱和骨髓细胞亚群分布及其与疾病进展的相关性。COVID-19患者表现出浆细胞样和髓样树突细胞绝对数量减少、单核细胞亚群分布不同以及单核细胞和中性粒细胞激活模式不同，同时HLA-DR单核细胞水平显着降低。我们发现，其中一些改变是所有 COVID-19 患者的典型改变，而另一些改变在疾病的不同阶段有所不同，并与炎症的生化参数相关。总的来说，这些数据表明，不仅淋巴系统，而且骨髓室也受到 SARS-CoV-2 感染的严重影响。
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