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Age and Location in Severity of COVID-19 Pathology: Do Lactoferrin and Pneumococcal Vaccination Explain Low Infant Mortality and Regional Differences?
BioEssays ( IF 3.2 ) Pub Date : 2020-08-31 , DOI: 10.1002/bies.202000076 Robert Root-Bernstein 1
BioEssays ( IF 3.2 ) Pub Date : 2020-08-31 , DOI: 10.1002/bies.202000076 Robert Root-Bernstein 1
Affiliation
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Two conundrums puzzle COVID‐19 investigators: 1) morbidity and mortality is rare among infants and young children and 2) rates of morbidity and mortality exhibit large variances across nations, locales, and even within cities. It is found that the higher the rate of pneumococcal vaccination in a nation (or city) the lower the COVID‐19 morbidity and mortality. Vaccination rates with Bacillus Calmette–Guerin, poliovirus, and other vaccines do not correlate with COVID‐19 risks, nor do COVID‐19 case or death rates correlate with number of people in the population with diabetes, obesity, or adults over 65. Infant protection may be due to maternal antibodies and antiviral proteins in milk such as lactoferrin that are known to protect against coronavirus infections. Subsequent protection might then be conferred (and correlate with) rates of Haemophilus influenzae type B (Hib) (universal in infants) and pneumococcal vaccination, the latter varying widely by geography among infants, at‐risk adults, and the elderly. Also see the video abstract here https://youtu.be/GODBYRbPL00.
中文翻译：
COVID-19病理严重程度的年龄和位置：乳铁蛋白和肺炎球菌疫苗接种能否说明低婴儿死亡率和地区差异？
两个难题困扰着COVID-19研究人员：1）发病率和死亡率在婴幼儿中很少见，并且2）发病率和死亡率在国家，地区甚至城市之间均表现出较大差异。发现一个国家（或城市）的肺炎球菌疫苗接种率越高，COVID-19的发病率和死亡率就越低。卡介苗芽孢杆菌，Guerin疫苗，脊髓灰质炎病毒和其他疫苗的疫苗接种率与COVID-19风险无关，COVID-19病例或死亡率与糖尿病，肥胖症或65岁以上成年人口的人数也不相关。保护作用可能是由于母乳中的母源抗体和抗病毒蛋白（如乳铁蛋白）而引起的，这些蛋白已知可以预防冠状病毒感染。然后可以赋予后续保护权（并与之相关）乙型流感嗜血杆菌（Hib）（在婴儿中普遍存在）和肺炎球菌疫苗接种，后者在地理上在婴儿，高危成年人和老年人中差异很大。另请参见https://youtu.be/GODBYRbPL00。
更新日期：2020-10-22
中文翻译：
COVID-19病理严重程度的年龄和位置：乳铁蛋白和肺炎球菌疫苗接种能否说明低婴儿死亡率和地区差异？
两个难题困扰着COVID-19研究人员：1）发病率和死亡率在婴幼儿中很少见，并且2）发病率和死亡率在国家，地区甚至城市之间均表现出较大差异。发现一个国家（或城市）的肺炎球菌疫苗接种率越高，COVID-19的发病率和死亡率就越低。卡介苗芽孢杆菌，Guerin疫苗，脊髓灰质炎病毒和其他疫苗的疫苗接种率与COVID-19风险无关，COVID-19病例或死亡率与糖尿病，肥胖症或65岁以上成年人口的人数也不相关。保护作用可能是由于母乳中的母源抗体和抗病毒蛋白（如乳铁蛋白）而引起的，这些蛋白已知可以预防冠状病毒感染。然后可以赋予后续保护权（并与之相关）乙型流感嗜血杆菌（Hib）（在婴儿中普遍存在）和肺炎球菌疫苗接种，后者在地理上在婴儿，高危成年人和老年人中差异很大。另请参见https://youtu.be/GODBYRbPL00。
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