Abstract Effective treatment of wound injuries can prevent infections and promote healing. In this work, a sprayed Pickering emulsion composed of chitosan nanoparticles, tea tree oil and curcumin was formulated. The shear thinning behaviour allowed this Pickering emulsion to spray even with a high viscosity provided by the aqueous phase containing chitosan nanoparticles. Moreover, the Pickering emulsion could recover to the high viscosity after spraying onto the wounds, leading to the long residence time and intimate contact. In addition, the Pickering emulsion provided a carrier to encapsulate the tea tree oil, which caused sustained-release effects and further strengthened tea tree oil's antibacterial activity towards the Gram-negative Escherichia coli (E. coli), Gram-positive Staphylococcus aureus (S. aureus) and Gram-positive methicillin-resistant Staphylococcus aureus (MRSA). Besides, this multi-phase system offered a platform to load with hydrophobic curcumin, leading to better synergistic healing effects. Meanwhile, the Pickering emulsion avoided the irritation and toxicity related to surfactants, which was far safer than the classical emulsion especially when used in the defective skin. All these excellent properties endowed this sprayed Pickering emulsion with promising prospects for wound healing.

中文翻译：

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用于伤口愈合的高抗菌活性喷雾Pickering乳液

摘要 伤口损伤的有效治疗可以预防感染和促进愈合。在这项工作中，配制了一种由壳聚糖纳米颗粒、茶树油和姜黄素组成的喷雾 Pickering 乳液。剪切稀化行为使这种 Pickering 乳液即使在含有壳聚糖纳米颗粒的水相提供的高粘度下也能喷涂。此外，Pickering乳液在喷到伤口上后可以恢复到高粘度，导致停留时间长和接触密切。此外，Pickering乳液提供了载体包裹茶树油，产生缓释作用，进一步增强茶树油对革兰氏阴性大肠杆菌（E.coli）、革兰氏阳性葡萄球菌（S . 金黄色葡萄球菌）和革兰氏阳性耐甲氧西林金黄色葡萄球菌（MRSA）。此外，这种多相系统提供了一个装载疏水姜黄素的平台，从而产生更好的协同愈合效果。同时，Pickering乳液避免了与表面活性剂相关的刺激和毒性，比经典乳液安全得多，尤其是用于缺陷皮肤时。所有这些优异的特性赋予了这种喷涂的 Pickering 乳液在伤口愈合方面具有广阔的前景。这比经典乳液安全得多，尤其是在有缺陷的皮肤上使用时。所有这些优异的特性赋予了这种喷涂的 Pickering 乳液在伤口愈合方面具有广阔的前景。这比经典乳液安全得多，尤其是在有缺陷的皮肤上使用时。所有这些优异的特性赋予了这种喷涂的 Pickering 乳液在伤口愈合方面具有广阔的前景。