While liposomes have proven to be effective drug delivery nanocarriers, their therapeutic attributes could be improved through the development of clinically viable triggered release strategies in which encapsulated drug contents could be selectively released at the sites of diseased cells. As such, a significant amount of research has been reported involving the development of stimuli-responsive liposomes and a broad range of strategies have been explored for driving content release. These have included the introduction of trigger groups at either the lipid headgroup or within the acyl chains that alter lipid self-assembly properties of known lipids as well as the rational design of lipid analogs programed to undergo conformational changes induced by events such as binding interactions. This review article describes advances in the design of stimuli-responsive liposome strategies with an eye towards emerging trends in the field.

虽然脂质体已被证明是有效的药物递送纳米载体，但可以通过开发临床上可行的触发释放策略来改善其治疗特性，在该策略中，可以在患病细胞的部位选择性地释放封装的药物成分。因此，已经报道了涉及刺激响应脂质体的开发的大量研究，并且已经探索了广泛的策略来驱动内容物的释放。这些包括在脂质头基或在酰基链内的触发基团的引入，其改变了已知脂质的脂质自组装特性，以及脂质类似物的合理设计，所述脂质类似物被编程为经历由诸如结合相互作用的事件诱导的构象变化。