Cachexia is a devastating, non-curable condition in many cancer patients that is marked by severe wasting of the muscle and fat tissue. Its prevention has been hampered by an insufficient knowledge of the underlying molecular mechanism(s) that lead to its pathogenesis. Suriben et al. (2020) now report the development and characterization of an antagonistic antibody for the previously identified GDF15-GFRAL axis that efficiently blocks tumor-induced body wasting in experimental animals.

中文翻译：

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针对癌症中身体浪费的抗体攻击。

恶病质是许多癌症患者的毁灭性，不可治愈的疾病，其特征是肌肉和脂肪组织的严重浪费。对导致其发病的潜在分子机制的了解不足，阻碍了其预防。Suriben等。（2020）现在报道了针对先前鉴定的GDF15-GFRAL轴的拮抗抗体的开发和表征，该拮抗抗体可有效阻断实验动物体内的肿瘤诱导的身体消瘦。