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A Percolation Lattice of Natural Selection as a Switch of Deterministic and Random Processes in the Mutation Flow
Biophysics Pub Date : 2020-05-01 , DOI: 10.1134/s0006350920030069
A. Ya. Garaeva , A. E. Sidorova , N. T. Levashova , V. A. Tverdislov

This review considers the basic models of mutation processes that occur during selection and drift. A basically new model was developed to describe the mutation flow through a percolation lattice of selection at the population level. Natural selection of optimal variants in the evolutionary flow of mutations was considered as a percolation filter, which acts as a physical tool that forms the mechanism of selection. The model was based on the concepts of self-organization in hierarchical structures of speciation, where the trigger properties of a cell (node) as a valve determine the deterministic component of the fixation of new mutations and the drift adds the element of randomness to the fixation of new mutations in mutation flows. Modes of mutation fixation were identified depending on the ratio of the cluster size of mutation carriers to the total size of the population and the selection and drift coefficients in a sequence of generations at the population level. A lower threshold of the percolation selection lattice was determined as the share of new mutations fixed under the influence of deterministic selection processes for a minimum reproducing cluster size.

中文翻译:

自然选择的渗透格作为突变流中确定性和随机过程的开关

本综述考虑了在选择和漂移过程中发生的突变过程的基本模型。开发了一个基本上新的模型来描述通过群体水平选择的渗透格子的突变流。突变进化流中最佳变体的自然选择被认为是一种渗透过滤器,它充当形成选择机制的物理工具。该模型基于物种形成层次结构中的自组织概念,其中作为阀门的细胞(节点)的触发特性决定了新突变固定的确定性成分,而漂移将随机性元素添加到固定突变流中的新突变。突变固定模式的确定取决于突变携带者的簇大小与种群总大小的比率以及种群水平世代序列中的选择和漂移系数。渗透选择格的下限阈值被确定为在最小再生簇大小的确定性选择过程的影响下固定的新突变的份额。
更新日期:2020-05-01
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