Currently, no specific drug and vaccine are available for the new coronavirus SARS-CoV-2, and nutritional supplementation should be helpful. This study tried to provide reference for protein supplementation. Specifically, in silico method was employed to simulate protein degradation by gastrointestinal enzymes and to produce a large number of active peptides, then, the binding ability of these peptides to SARS-CoV-2 spike protein receptor-binding domain (RBD) was evaluated. The results showed that wheat-derived alpha/beta-gliadin, oat-derived avenin, and ribulose bisphosphate carboxylase small chain of different origin could be good protein source in generating potent binders to SARS-CoV-2 spike RBD. In addition, some high-affinity oligopeptides (such as PISCR, VQVVN, PQQQF, etc.) were identified as potential binders of SARS-CoV-2 spike RBD. In summary, a number of plant proteins could be helpful for COVID-19 patients when supplemented with these proteins, the identified oligopeptides could be used as lead compound to design potential entry inhibitors against SARS-CoV-2.

中文翻译：

---

胃肠酶在硅中消化的植物蛋白作为 COVID-19 患者营养补充剂的潜力

目前尚无针对新型冠状病毒 SARS-CoV-2 的特效药物和疫苗，补充营养应该会有所帮助。本研究试图为蛋白质补充提供参考。具体而言，采用计算机模拟方法模拟胃肠酶对蛋白质的降解并产生大量活性肽，然后评估这些肽与SARS-CoV-2刺突蛋白受体结合域（RBD）的结合能力。结果表明，小麦来源的 α/β-麦醇溶蛋白、燕麦来源的燕麦蛋白和不同来源的核酮糖二磷酸羧化酶小链可能是产生有效结合 SARS-CoV-2 刺突 RBD 的良好蛋白质来源。此外，一些高亲和力寡肽（如 PISCR、VQVVN、PQQQF 等）被确定为 SARS-CoV-2 刺突 RBD 的潜在结合剂。