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Formation of gadolinium–ferritin from clinical magnetic resonance contrast agents
Nanoscale Advances ( IF 4.6 ) Pub Date : 2020-08-31 , DOI: 10.1039/c9na00567f
Jitka Neburkova 1 , Aaron M Rulseh 2 , Shery L Y Chang 3 , Helena Raabova 1 , Jana Vejpravova 4, 5 , Martin Dracinsky 1 , Jan Tarabek 1 , Jan Kotek 4 , Mohan Pingle 2 , Pavel Majer 1 , Josef Vymazal 2 , Petr Cigler 1
Affiliation  

Gadolinium deposition in the brain following administration of gadolinium-based contrast agents (GBCAs) has led to health concerns. We show that some clinical GBCAs form Gd3+–ferritin nanoparticles at (sub)nanomolar concentrations of Gd3+ under physiological conditions. We describe their structure at atomic resolution and discuss potential relevance for clinical MRI.

中文翻译:


从临床磁共振造影剂中形成钆铁蛋白



使用钆基造影剂(GBCA)后大脑中的钆沉积会导致健康问题。我们表明,一些临床 GBCA 在生理条件下以(亚)纳摩尔浓度的 Gd 3+形成 Gd 3+ -铁蛋白纳米颗粒。我们以原子分辨率描述它们的结构,并讨论其与临床 MRI 的潜在相关性。
更新日期:2020-08-31
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