Natural killer (NK) cells provide some of the earliest immune responses to infection, but when viruses manipulate or perturb the immune environment to alter NK cell function, this places the host at a disadvantage. Indeed, others and we observe that in the context of HIV/simian immunodeficiency virus (SIV) infection, although NK cells are not infected, they can become dysfunctional over time. Several studies have characterized protein and transcriptional profiles of NK cells during HIV/SIV infection, but none have examined whether the production of alternative transcripts and corresponding isoforms is modulated. This phenomenon occurs broadly in normal biology and in other disease states, and could provide a novel avenue of investigation that may yield better targets to restore or augment NK cell responses to HIV/SIV. Herein, we briefly summarize published and new data that may provide a perspective on how to target NK cell splice variants.

中文翻译：

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跳过 - 通过选择性剪接调整 NK 细胞以适应 HIV。

自然杀伤 (NK) 细胞提供一些针对感染的最早的免疫反应，但当病毒操纵或扰乱免疫环境以改变 NK 细胞功能时，这会使宿主处于不利地位。事实上，其他人和我们观察到，在 HIV/猿猴免疫缺陷病毒 (SIV) 感染的情况下，尽管 NK 细胞没有被感染，但随着时间的推移，它们可能会变得功能失调。一些研究已经描述了 HIV/SIV 感染期间 NK 细胞的蛋白质和转录特征，但没有一项研究检查替代转录物和相应亚型的产生是否受到调节。这种现象广泛发生在正常生物学和其他疾病状态中，并且可能提供一种新的研究途径，可能产生更好的目标来恢复或增强 NK 细胞对 HIV/SIV 的反应。在此，我们简要总结了已发表的数据和新数据，这些数据可能为如何靶向 NK 细胞剪接变体提供视角。