Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers,ACS Pharmacology & Translational Science

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Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers
ACS Pharmacology & Translational Science ( IF 4.9 ) Pub Date : 2020-08-31 , DOI: 10.1021/acsptsci.0c00099
Nadia R P W Hutten ₁ , Natasha L Mason ₁ , Patrick C Dolder ₁ , Eef L Theunissen ₁ , Friederike Holze ₂ , Matthias E Liechti ₂ , Nimmy Varghese ₃ , Anne Eckert ₃ , Amanda Feilding ₄ , Johannes G Ramaekers ₁ , Kim P C Kuypers ₁

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Despite preclinical evidence for psychedelic-induced neuroplasticity, confirmation in humans is grossly lacking. Given the increased interest in using low doses of psychedelics for psychiatric indications and the importance of neuroplasticity in the therapeutic response, this placebo-controlled within-subject study investigated the effect of single low doses of LSD (5, 10, and 20 μg) on circulating BDNF levels in healthy volunteers. Blood samples were collected every 2 h over 6 h, and BDNF levels were determined afterward in blood plasma using ELISA. The findings demonstrated an increase in BDNF blood plasma levels at 4 h (5 μg) and 6 h (5 and 20 μg) compared to that for the placebo. The finding that LSD acutely increases BDNF levels warrants studies in patient populations.

中文翻译：

低剂量 LSD 急剧增加健康志愿者的 BDNF 血浆水平

尽管有迷幻药诱导的神经可塑性的临床前证据，但严重缺乏对人类的证实。鉴于对使用低剂量迷幻药治疗精神病适应症的兴趣增加以及神经可塑性在治疗反应中的重要性，这项安慰剂对照的受试者内研究调查了单次低剂量 LSD（5、10 和 20 微克）对健康志愿者的循环 BDNF 水平。在 6 小时内每 2 小时收集一次血样，然后使用 ELISA 测定血浆中的 BDNF 水平。研究结果表明，与安慰剂相比，BDNF 血浆水平在 4 小时（5 微克）和 6 小时（5 和 20 微克）时有所增加。LSD 急剧增加 BDNF 水平的发现值得在患者群体中进行研究。

更新日期：2020-08-31

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