In this article, we commemorate the centenary of the discovery and clinical implementation of hyperosmolar therapy for the treatment of increased intracranial pressure (ICP). Following the pioneering work of anatomists Weed and McKibben in 1919, the use of hypertonic solutions was soon adopted into clinical practice, even though the preferred hypertonic agent, route of administration, and ideas regarding the physiological mechanism by which it reduced ICP diverged. These divergent conceptions and practices have continued to surround the use of hyperosmolar therapy into present times.

中文翻译：

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值得他们的盐：一百年的高渗疗法

在本文中，我们纪念高渗疗法用于治疗颅内压升高 (ICP) 的发现和临床实施一百周年。在 1919 年解剖学家 Weed 和 McKibben 的开创性工作之后，高渗溶液的使用很快被临床实践采用，尽管首选的高渗药物、给药途径和关于它降低 ICP 的生理机制的想法存在分歧。这些不同的概念和实践一直围绕着高渗疗法的使用直到现在。