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A Zn(ii)–organic cage with semirigid ligand for solvent-free cyanosilylation and inhibitory effect on ovarian cancer cell migration and invasion ability via regulating mi-RNA16 expression
Open Chemistry ( IF 2.1 ) Pub Date : 2020-08-29 , DOI: 10.1515/chem-2020-0144
Yan Yin 1 , Hong Mai 1 , Li-Ying Zhang 1 , Yan Liao 1 , Xu-Peng Liu 1 , Ye-Ping Wei 1
Affiliation  

Abstract [Zn6(L)4(DMF)2(H2O)4](1,4-Dioxane)2(DMF)10(H2O)4 (1, L = 4,4′,4″-(benzene-1,3,5-triyltris(oxy))tribenzoate), the metal-organic cage, was produced via Zn(NO3)2·6H2O reacting with the H3L ligand in the mixed solvent of DMF and water. The heterogeneous catalytic activities of the complex 1 for the aldehydes cyanidation under the conditions of free solvent were studied, which indicates that the removal of coordination solvents could greatly improve the catalytic activities. Furthermore, the inhibitory effect of the compound against the ovarian cancer cells was assessed. The mi-RNA16 relative expression level was measured after exposure to the compound with real-time reverse transcription-polymerase chain reaction. The invasion and migration of cells after compound treatment were also detected by the transwell method.

中文翻译:

具有半刚性配体的 Zn(ii)-有机笼用于无溶剂氰硅烷化并通过调节 mi-RNA16 表达抑制卵巢癌细胞迁移和侵袭能力

摘要 [Zn6(L)4(DMF)2(H2O)4](1,4-二恶烷)2(DMF)10(H2O)4 (1, L = 4,4′,4″-(benzo-1,在DMF和水的混合溶剂中,Zn(NO3)2·6H2O与H3L配体反应生成金属-有机笼3,5-三基三(氧基))三苯甲酸酯)。研究了配合物1在游离溶剂条件下对醛类氰化反应的多相催化活性,表明配位溶剂的去除可以大大提高催化活性。此外,评估了该化合物对卵巢癌细胞的抑制作用。在暴露于具有实时逆转录聚合酶链反应的化合物后测量了 mi-RNA16 的相对表达水平。Transwell法还检测了化合物处理后细胞的侵袭和迁移。
更新日期:2020-08-29
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