Abstract A dysprosium(iii) organic framework, {[Dy(H2O)(BTCTB)]·2H2O} n (1, H3BTCTB = 3,3′,3′′-[1,3,5-benzenetriyltris(carbonylimino)]tris-benzoic acid), was synthesized through the hydrothermal reaction of Dy(NO3)3 with the C3-symmetric organic ligand H3BTCTB at 160°C for 96 h. At the same time, the sensitivity of picric acid in water medium was tested with material 1 as the fluorescent sensor. The detection limit was 0.71 µM and K SV of this experiment was 8.55 × 104 M−1, which might be attributed to the presence of abundant amide groups in the framework of 1. In addition, the treatment effect of compound 1 against the NCI-H292 lung cancer cells was evaluated. The Cell Counting Kit-8 (CCK-8) method was conducted to measure the viability of cancer cell after treated through the compound 1. The DCFH-DA was applied for the determination of ROS. The relative expression of the inflammatory genes was measured with RT-PCR. The western blotting was conducted to detect the effect of the compound against MDM-2 levels in NCI-H292 lung cancer cells. The possible binding interactions in terms of binding poses are probed by performing molecular docking simulations.

中文翻译：

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Dy(iii)-有机框架作为荧光探针，用于高选择性检测苦味酸和对人肺癌细胞的治疗活性

摘要 镝(iii)有机骨架，{[Dy(H2O)(BTCTB)]·2H2O} n (1, H3BTCTB = 3,3',3''-[1,3,5-benzotriyltris(carbonylimino)]tris -苯甲酸），通过 Dy(NO3)3 与 C3 对称有机配体 H3BTCTB 在 160°C 下水热反应 96 小时合成。同时，以材料1为荧光传感器测试苦味酸在水介质中的灵敏度。本实验的检测限为 0.71 µM，K SV 为 8.55 × 104 M-1，这可能是由于 1 框架中存在丰富的酰胺基。此外，化合物 1 对 NCI-评估了 H292 肺癌细胞。用Cell Counting Kit-8(CCK-8)法测定化合物1处理后癌细胞的存活率。DCFH-DA用于ROS的测定。用RT-PCR测量炎症基因的相对表达。进行蛋白质印迹以检测化合物对 NCI-H292 肺癌细胞中 MDM-2 水平的影响。通过执行分子对接模拟来探测在结合姿势方面可能的结合相互作用。