Cellular metabolic reprogramming is an important mechanism by which cells rewire their metabolism to promote proliferation and cell growth. This process has been mostly studied in the context of tumorigenesis, but less is known about its relevance for nonpathological processes and how it affects whole-animal physiology. Here, we show that metabolic reprogramming in Drosophila female germline cells affects nutrient preferences of animals. Egg production depends on the upregulation of the activity of the pentose phosphate pathway in the germline, which also specifically increases the animal’s appetite for sugar, the key nutrient fuelling this metabolic pathway. We provide functional evidence that the germline alters sugar appetite by regulating the expression of the fat-body-secreted satiety factor Fit. Our findings demonstrate that the cellular metabolic program of a small set of cells is able to increase the animal’s preference for specific nutrients through inter-organ communication to promote specific metabolic and cellular outcomes.

细胞代谢重编程是细胞重新排列其代谢以促进增殖和细胞生长的重要机制。该过程主要在肿瘤发生的背景下进行了研究，但对它与非病理过程的相关性以及它如何影响整个动物生理的了解却很少。在这里，我们显示了果蝇中的代谢重编程雌性生殖细胞会影响动物的营养偏好。卵的产生取决于种系中戊糖磷酸途径的活性上调，这也特别增加了动物对糖的食欲，糖是促进这种代谢途径的关键营养素。我们提供功能证据，表明种系通过调节脂肪分泌的饱腹感因子Fit的表达来改变糖食。我们的发现表明，一小部分细胞的细胞代谢程序能够通过器官间交流促进特定代谢和细胞结局，从而增加动物对特定营养素的偏好。