To trigger an adequate humoral immune response while ensuring self-tolerance, B cell activation is tightly controlled. A new study indicates that an NR4A-enforced built-in brake fine-tunes the early phase of transcriptional reprogramming induced by BCR stimulation.

中文翻译：

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NR4A对B细胞反应施加制动。

为了触发足够的体液免疫反应，同时确保自我耐受，B细胞激活受到严格控制。一项新研究表明，NR4A增强的内置制动器可以微调BCR刺激诱导的转录重编程的早期阶段。