While the formation and concentration of urine are better understood, how kidney epithelial cells generate the energy to drive these functions has remained unclear. A study now reveals that shear stress originating from urinary flow is sensed by the primary cilia of cortical epithelial cells and stimulates lipolysis and oxidative metabolism.

中文翻译：

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剪应力打开了初级纤毛和脂肪吞噬。

虽然人们对尿液的形成和浓度有了更好的了解，但肾上皮细胞如何产生能量来驱动这些功能尚不清楚。现在的一项研究表明，皮层上皮细胞的初级纤毛可以感知到源自尿流的剪切应力，并刺激脂肪分解和氧化代谢。