Abstract

In the current study, two new transition metal-organic coordination polymers (CPs) with the chemical formula of [Cu(L)(OBA)(H₂O)]_n (1) and [Co(L)(OBA)]_n (2) (H₂OBA = 4,4(L)(OBA)]dy, two new traL = 1,4-bis(benzimidazol-1-yl)-2-butylene) were synthesized under solvothermal reaction conditions by using different metal centers as the nodes, which results in the structural differences in the as-prepared products although the same organic ligands are used. For the acute kidney injury treatment, their treatment activity on the acute kidney injury was evaluated and the related mechanism was explored at the same time. First of all, the ELISA detection kit was performed to determine the content of the neutrophil gelatinase-associated lipocalin (Nagl) in the urine after compounds 1 and 2 treatment. Besides, the real-time RT-PCR was conducted and the relative expression of the jak and stat in the glomerular epithelial cells was measured as well.

摘要

在当前的研究中，两种新的化学式为[Cu（L）（OBA）（H ₂ O）] _n（1）和[Co（L）（OBA）] _n的过渡金属有机配位聚合物（CPs）（2）（高₂OBA = 4,4（L）（OBA）] dy，在溶剂热反应条件下，以不同的金属中心为节点，合成了两个新的traL = 1,4-双（苯并咪唑-1-基）-2-丁烯，尽管使用了相同的有机配体，但这导致了所制备产品的结构差异。对于急性肾损伤的治疗，评估了它们对急性肾损伤的治疗活性，并探讨了相关机制。首先，进行ELISA检测试剂盒以确定化合物1和2处理后尿液中与中性粒细胞明胶酶相关的脂钙蛋白（Nagl）的含量。此外，还进行了实时RT-PCR，并分析了jak和stat的相对表达。 还测量了肾小球上皮细胞中的α-淀粉样蛋白。