Diabetes mellitus is a serious worldwide metabolic disease, which is accompanied by hyperglycaemia and affects all organs and body system. Zinc (Zn) is a basic cofactor for many enzymes, which also plays an important role in stabilising the structure of insulin. Liver is the most important target organ after pancreas in diabetic complications. In this study, we aimed to investigate the protective role of Zn in liver damage in streptozotocin (STZ)‐induced diabetes mellitus. There are four experimental groups of female Swiss albino rats: group I: control; group II: control + ZnSO₄; group III: STZ‐induced diabetic animals and group IV: STZ‐diabetic + ZnSO₄. To induce diabetes, STZ was injected intraperitoneally (65 mg/kg). ZnSO₄ (100 mg/kg) was given daily to groups II and IV by gavage for 60 days. At the end of the experiment, rats were killed under anaesthesia and liver tissues were collected. In the diabetic group, hexose, hexosamine, fucose, sialic acid levels, arginase, adenosine deaminase, tissue factor activities and protein carbonyl levels increased, whereas catalase, superoxide dismutase, glutathione‐S‐transferase, glutathione peroxidase, glutathione reductase and Na⁺/K⁺‐ATPase activities decreased. The administration of Zn to the diabetic group reversed all the negative effects/activities. According to these results, we can suggest that Zn has a protective role against STZ‐induced diabetic liver damage.

中文翻译：

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通过不同的生化参数证明锌对实验性糖尿病肝脏损害的保护作用。

糖尿病是一种严重的全球性代谢疾病，伴有高血糖症，并影响所有器官和身体系统。锌（Zn）是许多酶的基本辅助因子，在稳定胰岛素的结构中也起着重要作用。在糖尿病并发症中，肝脏是仅次于胰腺的最重要的靶器官。在这项研究中，我们旨在研究锌在链脲佐菌素（STZ）诱导的糖尿病中对肝损伤的保护作用。瑞士白化病雌性大鼠有四个实验组：第一组：对照组；第二组：对照组。第二组：对照+ ZnSO ₄；第三组：STZ诱导的糖尿病动物，第四组：STZ糖尿病+ ZnSO ₄。为了诱发糖尿病，腹膜内注射STZ（65 mg / kg）。硫酸锌₄每天通过管饲法向II组和IV组（100 mg / kg）给药60天。实验结束时，在麻醉下杀死大鼠并收集肝组织。在糖尿病组中，己糖，己糖胺，岩藻糖，唾液酸水平，精氨酸酶，腺苷脱氨酶，组织因子活性和蛋白质羰基水平升高，而过氧化氢酶，超氧化物歧化酶，谷胱甘肽-S-转移酶，谷胱甘肽过氧化物酶，谷胱甘肽还原酶和Na ⁺ / K ⁺ -ATPase活性降低。将锌给予糖尿病组可逆转所有负面影响/活性。根据这些结果，我们可以认为锌对STZ诱导的糖尿病性肝损伤具有保护作用。