Leveraging sequence‐based faecal microbial community survey data to identify alterations in gut microbiota among patients with Parkinson's disease,European Journal of Neuroscience

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Leveraging sequence‐based faecal microbial community survey data to identify alterations in gut microbiota among patients with Parkinson's disease
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2020-08-31 , DOI: 10.1111/ejn.14952
Tianyi Ji _{1,

2} , Hongyan Huang _{1,

3} , Jiaxuan Liu _{1,

4} , Tian Peng _{1,

3} , Xiazhu Zhou _{1,

3} , Qin Tan _{1,

3} , Jiaguo Yuan _{1,

3} , Huan Hua _{1,

3} , Songtao Ding ₁ , Handeng Liu _{1,

5}

Affiliation

Parkinson's disease is a common degenerative disease of the elderly. Although the majority of studies have focused on the central nervous system (CNS) features of Parkinson's disease, recent findings suggest there is a functional link between the gut microbiome and the hallmarks of the disease. PubMed, Web of Science, EMBASE and other Chinese and English databases were searched for relevant literature. Studies on changes to intestinal microbiota in Parkinson's patients were retrieved and systematically reviewed. Quality filtering, clustering and species annotation were performed on 16s sequencing raw data from retrieved studies to achieve comparability across studies. Alpha‐diversity indices and a random effect model were used to analyse significantly altered microbiota. A total of nine studies were included in this retrospective analysis, four of which contained raw data. Alpha diversity was significantly different between control and Parkinson's disease patients in two of the four studies. Using the raw data from four individual studies, we observed differences in the phlya Bacteroidetes and Actinobacteria. Additionally, differences were observed between control and Parkinson's disease patients at the level of family (Prevotellacaea and Lactobacillaceae) and genus (Bifidobacterium and Clostridium). This study confirmed that changes in the microbiome are a consistent feature of Parkinson's disease patients and, therefore, may contribute to the onset of disease.

中文翻译：

利用基于序列的粪便微生物群落调查数据来确定帕金森氏病患者肠道菌群的变化

帕金森氏病是老年人的常见退行性疾病。尽管大多数研究都集中在帕金森氏病的中枢神经系统（CNS）特征上，但最近的发现表明，肠道微生物组与疾病特征之间存在功能联系。在PubMed，Web of Science，EMBASE和其他中英文数据库中搜索相关文献。检索并系统评价了帕金森氏病患者肠道菌群变化的研究。对来自检索到的研究的原始数据进行16s测序，进行质量过滤，聚类和物种注释，以实现研究之间的可比性。使用阿尔法多样性指数和随机效应模型来分析明显改变的微生物群。这项回顾性分析总共包括九项研究，其中四项包含原始数据。在四项研究中的两项研究中，对照组和帕金森氏病患者之间的阿尔法多样性差异显着。使用来自四项单独研究的原始数据，我们观察到了phlya的差异拟杆菌和放线菌。此外，控制和帕金森氏症患者之间观察到的家庭（水平的差异Prevotellacaea和乳酸杆菌）及属（双歧杆菌和梭状芽孢杆菌）。这项研究证实，微生物组的变化是帕金森氏病患者的一贯特征，因此可能有助于疾病的发作。

更新日期：2020-08-31

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