当前位置：
X-MOL 学术
›
Genes Cells
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Role for phagocytosis in the prevention of neoplastic transformation in Drosophila.
Genes to Cells ( IF 1.3 ) Pub Date : 2020-08-31 , DOI: 10.1111/gtc.12804 Min Zhang 1 , Kaz Nagaosa 2 , Yuji Nakai 2 , Tetsuo Yasugi 3 , Masako Kushihiki 2 , Dini Rahmatika 1 , Makoto Sato 3 , Akiko Shiratsuchi 4 , Yoshinobu Nakanishi 1
Genes to Cells ( IF 1.3 ) Pub Date : 2020-08-31 , DOI: 10.1111/gtc.12804 Min Zhang 1 , Kaz Nagaosa 2 , Yuji Nakai 2 , Tetsuo Yasugi 3 , Masako Kushihiki 2 , Dini Rahmatika 1 , Makoto Sato 3 , Akiko Shiratsuchi 4 , Yoshinobu Nakanishi 1
Affiliation
|
Immunity is considered to be involved in the prevention of cancer. Although both humoral and cellular immune reactions may participate, underlying mechanisms have yet to be clarified. The present study was conducted to clarify this issue using a Drosophila model, in which neoplastic transformation was induced through the simultaneous inhibition of cell‐cycle checkpoints and apoptosis. We first determined the location of hemocytes, blood cells of Drosophila playing a role of immune cells, in neoplasia‐induced and normal larvae, but there was no significant difference between the two groups. When gene expression pattern in larval hemocytes was determined, the expression of immunity‐related genes including those necessary for phagocytosis was reduced in the neoplasia model. We then asked the involvement of phagocytosis in the prevention of neoplasia examining animals where the expression of engulfment receptors instead of apoptosis was retarded. We found that the inhibition of engulfment receptor expression augmented the occurrence of neoplasia induced by a defect in cell‐cycle checkpoints. This suggested a role for phagocytosis in the prevention of neoplastic transformation in Drosophila.
中文翻译：
吞噬作用在果蝇肿瘤转化的预防中的作用。
免疫被认为与癌症的预防有关。尽管体液和细胞免疫反应均可能参与，但尚需阐明其潜在机制。本研究使用果蝇模型进行了阐明，其中通过同时抑制细胞周期检查点和凋亡来诱导肿瘤转化。我们首先确定了果蝇血细胞，血细胞的位置在肿瘤诱导的幼虫和正常幼虫中发挥免疫细胞的作用，但两组之间没有显着差异。确定幼虫血细胞中的基因表达模式后，在瘤形成模型中，与免疫相关的基因（包括吞噬作用所必需的基因）的表达降低了。然后，我们询问吞噬作用是否参与了预防瘤形成动物的研究，在动物体内，吞噬受体的表达而不是细胞凋亡受到了抑制。我们发现吞噬受体表达的抑制增加了细胞周期检查点缺陷引起的赘生物的发生。这暗示吞噬作用在果蝇的肿瘤转化的预防中起作用。
更新日期：2020-10-19
中文翻译：
吞噬作用在果蝇肿瘤转化的预防中的作用。
免疫被认为与癌症的预防有关。尽管体液和细胞免疫反应均可能参与，但尚需阐明其潜在机制。本研究使用果蝇模型进行了阐明，其中通过同时抑制细胞周期检查点和凋亡来诱导肿瘤转化。我们首先确定了果蝇血细胞，血细胞的位置在肿瘤诱导的幼虫和正常幼虫中发挥免疫细胞的作用，但两组之间没有显着差异。确定幼虫血细胞中的基因表达模式后，在瘤形成模型中，与免疫相关的基因（包括吞噬作用所必需的基因）的表达降低了。然后，我们询问吞噬作用是否参与了预防瘤形成动物的研究，在动物体内，吞噬受体的表达而不是细胞凋亡受到了抑制。我们发现吞噬受体表达的抑制增加了细胞周期检查点缺陷引起的赘生物的发生。这暗示吞噬作用在果蝇的肿瘤转化的预防中起作用。
京公网安备 11010802027423号