Dielectrophoretically Modulated Optical Spectroscopy of Colloidal Nanoparticle Solutions in Microfluidic Channels,Particle & Particle Systems Characterization

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Dielectrophoretically Modulated Optical Spectroscopy of Colloidal Nanoparticle Solutions in Microfluidic Channels
Particle & Particle Systems Characterization ( IF 2.7 ) Pub Date : 2020-08-31 , DOI: 10.1002/ppsc.202000187
Clyde Midelet _{1,

2} , Martinus H. V. Werts _{1,

2}

Affiliation

Optical spectroscopic techniques (e.g., extinction, scattering, and fluorescence spectroscopies) are important for the analysis of colloidal solutions of nanoparticles (NPs). They are routinely applied to plasmonic and quantum‐dot NP samples assuming that these contain a single population of particles with modest size and shape dispersity. However, these spectroscopic techniques become less effective when the sample is a mixture of particles with different sizes, shapes, or composition. Here, an original microfluidic method is proposed for the optical spectroscopic analysis of colloidal NP solutions that combines periodic trapping of NPs by dielectrophoresis (DEP) with in situ optical extinction spectroscopy. The periodic trapping leads to modulation of the continuously monitored optical spectrum depending on the DEP properties of the NPs. DEP‐modulated spectroscopy is demonstrated using colloidal gold NPs as small as 40 nm diameter. It is found that the DEP modulation is significantly enhanced when employing suitable microfluidic flow over a multielectrode array. Finally, it is shown that the method can identify and characterize the NP species simultaneously present in a mixture of 40 and 80 nm gold NPs, opening the way toward optical spectroscopic analysis of higher complexity NP mixtures through the combination of the DEP‐modulated spectroscopy with chemometric methods.

中文翻译：

胶态纳米粒子溶液在微流控通道中的介电泳调制光谱。

光谱技术（例如消光，散射和荧光光谱学）对于纳米颗粒（NPs）的胶体溶液的分析很重要。假定它们包含具有适度大小和形状分散性的单个粒子种群，它们通常应用于等离子和量子点NP样品。但是，当样品是具有不同大小，形状或组成的颗粒的混合物时，这些光谱技术的效果会降低。在这里，提出了一种原始的微流体方法，用于胶体NP溶液的光谱分析，该方法结合了介电电泳（DEP）和原位消光光谱法对NP的定期捕获。周期性捕获导致根据NP的DEP特性对连续监控的光谱进行调制。使用直径小于40 nm的胶体金NP证明了DEP调制光谱。发现当在多电极阵列上采用合适的微流体流时，DEP调制显着增强。最后，结果表明该方法可以识别和表征同时存在于40和80 nm金纳米颗粒混合物中的NP种类，这通过DEP调制光谱仪与高纯NP混合物的组合为光谱分析更高复杂性的NP混合物开辟了道路化学计量学方法。

更新日期：2020-10-21

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