Ti and Ti alloys are bioinert materials and two frequent problems associated with them are bacterial infection and lack of osteogenic potential for rapid bone integration. To overcome the problems, the present study incorporated strontium (Sr) and silver (Ag) simultaneously into porous TiO₂ coatings through a single‐step technique, micro‐arc oxidation (MAO). Incorporation of Sr and Ag brought no significant changes to coating micromorphology and physicochemical properties, but endowed TiO₂ coatings with both strong antibacterial activity and osteogenic ability. Antibacterial activity increased with Ag contents in the coatings. When Ag content reached 0.58 wt%, the coating showed both excellent short‐term (100.0%) and long‐term (77.6%) antibacterial activities. Sr/Ag‐containing coatings with 18.23 wt% Sr and 0.58 wt% Ag also presented good cytocompatibility for preosteoblast adhesion and proliferation, and promoted preosteoblast osteogenic differentiation both short‐termly and long‐termly. However, higher Ag content (1.29 wt%) showed toxic effects to preosteoblasts. In summary, MAO is a simple and effective way to incorporate Sr and Ag into porous TiO₂ coatings and Sr/Ag‐containing TiO₂ coating with 18.5 wt% Sr and 0.58 wt% Ag has both good osteogenic activity and strong antibacterial capability short‐termly and long‐termly. Therefore, such coatings are valuable for clinical application to strengthen osseointegration and long‐term high quality use of titanum implants.

中文翻译：

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微弧氧化制备的含锶/银多孔二氧化钛涂层的成骨和抗菌性能评价

Ti 和 Ti 合金是生物惰性材料，与它们相关的两个常见问题是细菌感染和缺乏快速骨整合的成骨潜力。为了克服这些问题，本研究通过单步技术微弧氧化（MAO）将锶（Sr）和银（Ag）同时掺入多孔TiO _{2涂层中。}Sr和Ag的掺入对涂层的微观形貌和物理化学性质没有显着影响，但赋予了TiO ₂涂层具有很强的抗菌活性和成骨能力。抗菌活性随着涂层中银含量的增加而增加。当Ag含量达到0.58 wt%时，涂层表现出优异的短期（100.0%）和长期（77.6%）抗菌活性。含有 18.23 wt% Sr 和 0.58 wt% Ag 的 Sr/Ag 涂层对前成骨细胞粘附和增殖也表现出良好的细胞相容性，并在短期和长期内促进前成骨细胞成骨分化。然而，较高的银含量（1.29 wt%）对前成骨细胞显示出毒性作用。总之，MAO 是将 Sr 和 Ag 掺入多孔 TiO ₂涂层和含 Sr/Ag 的 TiO _{2中的一种简单有效的方法}18.5 wt% Sr和0.58 wt% Ag涂层具有良好的成骨活性和强的短期和长期抗菌能力。因此，这种涂层对于临床应用以加强骨整合和钛植入物的长期高质量使用具有重要意义。