Celiac disease (CD) is an autoimmune disorder that occurs in genetically predisposed people in which the ingestion of gluten leads to damage in the small intestine that clinically presents with malabsorption‐related symptoms. CD can also be the underlying cause of several non‐gastrointestinal symptoms. This review summarizes evidence on the relationship between CD and gynecological/obstetric disorders like reproductive failures. Although much has been reported on such a linkage, the pathogenic mechanisms remain unclear, especially those underlying extra‐gastrointestinal clinical manifestations. Studies conducted on celiac subjects presenting gynecological/obstetric disorders have pointed to intestinal malabsorption, coagulation alterations, immune‐mediated tissue damage, and endometrial inflammation as the main responsible pathogenic mechanisms. Currently, however, the knowledge of such mechanisms is insufficient, and further studies are needed to gain a more thorough understanding of the matter.

中文翻译：

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乳糜泻和生殖障碍：致病机制的最新进展。

乳糜泻 (CD) 是一种自身免疫性疾病，发生在遗传易感人群中，其中摄入麸质会导致小肠损伤，临床上出现与吸收不良相关的症状。CD 也可能是几种非胃肠道症状的根本原因。本综述总结了 CD 与生殖障碍等妇科/产科疾病之间关系的证据。尽管关于这种联系的报道很多，但致病机制仍不清楚，尤其是那些潜在的胃肠外临床表现。对出现妇科/产科疾病的乳糜泻患者进行的研究表明，肠道吸收不良、凝血功能改变、免疫介导的组织损伤和子宫内膜炎症是主要的致病机制。