Microrobots offer transformative solutions for non‐invasive medical interventions due to their small size and untethered operation inside the human body. However, they must face the immune system as a natural protection mechanism against foreign threats. Here, non‐immunogenic stealth zwitterionic microrobots that avoid recognition from immune cells are introduced. Fully zwitterionic photoresists are developed for two‐photon polymerization 3D microprinting of hydrogel microrobots with ample functionalization: tunable mechanical properties, anti‐biofouling and non‐immunogenic properties, functionalization for magnetic actuation, encapsulation of biomolecules, and surface functionalization for drug delivery. Stealth microrobots avoid detection by macrophage cells of the innate immune system after exhaustive inspection (>90 hours), which has not been achieved in any microrobotic platform to date. These versatile zwitterionic materials eliminate a major roadblock in the development of biocompatible microrobots, and will serve as a toolbox of non‐immunogenic materials for medical microrobot and other device technologies for bioengineering and biomedical applications.

中文翻译：

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两性离子 3D 打印非免疫性隐形微型机器人。

微型机器人由于体积小且可以在人体内不受束缚地操作，因此为非侵入性医疗干预提供了变革性的解决方案。然而，它们必须面对免疫系统作为抵御外来威胁的天然保护机制。在这里，引入了避免被免疫细胞识别的非免疫原性隐形两性离子微型机器人。全两性离子光刻胶被开发用于水凝胶微型机器人的双光子聚合 3D 微打印，具有丰富的功能：可调节的机械性能、抗生物污损和非免疫原性、磁驱动功能化、生物分子封装以及用于药物输送的表面功能化。隐形微型机器人在详尽检查（ > 90小时）后可避免先天免疫系统巨噬细胞的检测，迄今为止任何微型机器人平台都尚未实现这一点。这些多功能两性离子材料消除了生物相容性微型机器人开发中的主要障碍，并将作为医疗微型机器人和生物工程和生物医学应用的其他设备技术的非免疫原性材料的工具箱。