A simple, efficient, environmentally friendly, and ethanol assisted mechanochemical approach for the synthesis of Indoloindole pyrimidine has been developed through a simple mortar and pestle under catalyst-free grinding method. The present protocol is green and associated with easy workup step, high yield of product, short reaction time, and bear an extensive range of functional groups.

中文翻译：

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研磨诱导的无催化剂的吲哚并吲哚嘧啶的多组分合成

通过简单的研钵和杵在无催化剂的研磨方法下，开发了一种简单，高效，环保和乙醇辅助的机械化学方法来合成吲哚并吲哚嘧啶。本方案是绿色的，并且与后处理步骤容易，产物的产率高，反应时间短以及具有广泛的官能团有关。