Sleep problems and depression are both common and have a high impact on quality of life. They are also strongly associated and commonly occur together. During the reproductive age, both sleep problems and depression are almost twice as common in women than men. Epidemiological studies show that women experience more sleep problems and depressive symptoms around times when sex hormones change, such as puberty and menopause, but it is unclear what effect sex hormones have on sleep problems and depression.

This systematic review aims to summarize and evaluate studies that investigated the relationship between sex hormones, sleep and depression.

Systematic search resulted in 2895 articles, of which 13 met inclusion criteria.

Depressed patients showed worse sleep than controls, but no significant difference in endogenous hormone levels was found. Additionally, higher endogenous estrogen was associated with better sleep in controls, but associations between endogenous sex hormones and depressive symptoms were inconclusive. More research on the effect of sex hormones on sleep and depression is necessary.

睡眠问题和抑郁症很常见，并且对生活质量有很大影响。它们也紧密相关，通常一起出现。在生育年龄，女性的睡眠问题和抑郁症几乎是男性的两倍。流行病学研究表明，女性在性激素变化时会经历更多的睡眠问题和抑郁症状，例如青春期和更年期，但尚不清楚性激素对睡眠问题和抑郁症有何影响。

本系统综述旨在总结和评估研究性激素，睡眠与抑郁之间关系的研究。

系统搜索结果共有2895篇文章，其中13篇符合纳入标准。

抑郁症患者的睡眠质量较对照组差，但内源激素水平无显着差异。此外，内源性雌激素水平越高，对照组的睡眠越好，但内源性激素与抑郁症状之间的关系尚无定论。有必要对性激素对睡眠和抑郁的影响进行更多研究。