A trial was conducted to evaluate the antiviral activity and immunomodulatory effect of B-Caryophyllene (BCP) using NDV as a viral model. First, an in ovo experiment was conducted to estimate the antiviral mechanism of BCP. Next, an in vivo experiment was designed to confirm its antiviral efficacy as well as its immunomodulatory and growth promoting ability. According to the in ovo experiment, BCP possesses antiviral influence up to 61.7% when treated before or during NDV infection. Oral supplementation of chickens with two doses of BCP (200 and 400 μg/bird) resulted in a significant increase in the NDV HI-Ab responses and a significant increase in interferon-α signaling cytokines. These obvious immunomodulatory effects improved the bird clinical protection against virulent NDV challenge. To conclude, we introduced a new compound for the poultry industry sector that has antiviral and immunostimulant properties when supplemented orally before or during NDV infection.

使用NDV作为病毒模型进行了一项试验，以评估B-石竹烯（BCP）的抗病毒活性和免疫调节作用。首先，进行卵内实验以评估BCP的抗病毒机制。接下来，设计了体内实验以确认其抗病毒功效以及其免疫调节和生长促进能力。根据卵内实验，在NDV感染之前或期间进行治疗时，BCP的抗病毒作用高达61.7％。口服补充两种剂量的BCP（200和400μg/只鸡）的鸡导致NDV HI-Ab反应显着增加，干扰素-α信号细胞因子显着增加。这些明显的免疫调节作用改善了禽类对强毒NDV攻击的临床保护。最后，