Stroke has become the most disabling and the second most fatal disease in the world. It has been a top priority to reveal the pathophysiology of stroke at cellular and molecular levels. A large number of long non-coding RNAs (lncRNAs) are identified to be abnormally expressed after stroke. Here, we summarize 35 lncRNAs associated with stroke, and clarify their functions on the prognosis through signal transduction and predictive values as biomarkers. Changes in the expression of these lncRNAs mediate a wide range of pathological processes in stroke, including apoptosis, inflammation, angiogenesis, and autophagy. Based on the exploration of the functions and mechanisms of lncRNAs in stroke, more timely, accurate predictions and more effective, safer treatments for stroke could be developed.

中风已成为世界上最致残和第二致命的疾病。在细胞和分子水平上揭示中风的病理生理学一直是当务之急。大量长链非编码 RNA (lncRNA) 被鉴定为在卒中后异常表达。在这里，我们总结了与中风相关的 35 个 lncRNA，并通过信号转导和作为生物标志物的预测值阐明了它们对预后的作用。这些 lncRNA 表达的变化介导了中风的广泛病理过程，包括细胞凋亡、炎症、血管生成和自噬。在探索lncRNA在脑卒中的功能和机制的基础上，可以开发出更及时、更准确的预测和更有效、更安全的脑卒中治疗方法。