Background/Aims To determine associations between HLAB27-positive uveitis, ethnicity and seronegative spondyloarthropathies (SpAs) in a New Zealand population. Methods Retrospective observational cohort study. Medical records of all subjects with uveitis at Auckland District Health Board from 2008 to 2018 were reviewed for HLAB27 status, age of presentation, ethnicity and SpA. Results In 10 years, 2567 subjects with uveitis were seen and 492 (19.2%) were HLAB27-positive. Of the HLAB27-positive subjects, 301 were male (60.3%) and median age was 37.8 years (IQR 29.7–50.0). Ethnicities were Caucasian (n=298, 60.6%), Asian (n=111, 22.6%), Maori (n=41, 8.2%) and Pacific Islander (n=38, 7.7%). Uveitis classification was anterior (n=478, 97.2%), intermediate (n=40, 8.1%), panuveitis (n=9, 1.8%) and scleritis (n=2, 0.4%). Maori or Pacific Islander ethnicity was associated with intermediate or panuveitis (p=0.003). Ankylosing spondylitis occurred in 163 subjects (33.1%); 29 (17.8%) were Maori or Pacific Islander. Subjects were younger (OR 0.982, p=0.009) and male (OR 1.980, p=0.001). There was no association with ethnicity or uveitis classification. Psoriatic arthritis (PsA) occurred in 11 subjects (2.2%). Chronic anterior uveitis was more common with PsA (27.3% vs 7.1%, p=0.023). There was no association with gender or ethnicity. Inflammatory bowel disease occurred in 19 subjects (3.8%) and reactive arthritis occurred in 14 subjects (2.8%). None developed chronic anterior uveitis (p=0.246 and p=0.227, respectively). There was no association with age at presentation, gender, ethnicity or uveitis classification. Conclusion This cohort of New Zealand-based subjects with HLAB27-positive uveitis showed a difference in age and ethnicity in uveitis subtypes and SpAs.

中文翻译：

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HLAB27 葡萄膜炎中脊柱关节病的发病率随年龄和种族而变化

背景/目的 确定新西兰人群中 HLAB27 阳性葡萄膜炎、种族和血清阴性脊柱关节病 (SpAs) 之间的关联。方法 回顾性观察性队列研究。对 2008 年至 2018 年奥克兰地区卫生局所有葡萄膜炎受试者的医疗记录进行了 HLAB27 状态、就诊年龄、种族和 SpA 的审查。结果 10 年中，有 2567 名葡萄膜炎受试者出现，492 人（19.2%）为 HLAB27 阳性。在 HLAB27 阳性受试者中，301 人为男性（60.3%），中位年龄为 37.8 岁（IQR 29.7-50.0）。种族是高加索人（n=298, 60.6%）、亚洲人（n=111, 22.6%）、毛利人（n=41, 8.2%）和太平洋岛民（n=38, 7.7%）。葡萄膜炎分类为前葡萄膜炎（n=478, 97.2%）、中葡萄膜炎（n=40, 8.1%）、全葡萄膜炎（n=9, 1.8%）和巩膜炎（n=2, 0.4%）。毛利人或太平洋岛民种族与中度或全葡萄膜炎相关（p=0.003）。163 名受试者（33.1%）发生强直性脊柱炎；29 人（17.8%）是毛利人或太平洋岛民。受试者更年轻（OR 0.982，p=0.009）和男性（OR 1.980，p=0.001）。与种族或葡萄膜炎分类无关。11 名受试者 (2.2%) 发生银屑病关节炎 (PsA)。慢性前葡萄膜炎在 PsA 中更为常见（27.3% vs 7.1%，p=0.023）。与性别或种族无关。19 名受试者 (3.8%) 发生炎症性肠病，14 名受试者 (2.8%) 发生反应性关节炎。没有人发展为慢性前葡萄膜炎（分别为 p = 0.246 和 p = 0.227）。与就诊年龄、性别、种族或葡萄膜炎分类无关。